Inhibition of hepatic sulfatase‐2 In Vivo: A novel strategy to correct diabetic dyslipidemia

H. Carlijne Hassing, Hans Mooij, Shuling Guo, Brett P. Monia, Keyang Chen, Wim Kulik, Geesje M. Dallinga‐Thie, Max Nieuwdorp, Erik S.G. Stroes, Kevin Jon Williams – 11 January 2012 – Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceride‐rich lipoproteins (TRLs). We recently reported that livers from T2DM db/db mice markedly overexpress the heparan sulfate glucosamine‐6‐O‐endosulfatase‐2 (SULF2), an enzyme that removes 6‐O sulfate groups from heparan sulfate proteoglycans (HSPGs) and suppresses uptake of TRLs by cultured hepatocytes.

A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma‐like gene expression trait and epithelial‐mesenchymal transition

Jae Yeon Seok, Deuk Chae Na, Hyun Goo Woo, Massimo Roncalli, So Mee Kwon, Jeong Eun Yoo, Ei Yong Ahn, Gwang Il Kim, Jin‐Sub Choi, Young Bae Kim, Young Nyun Park – 11 January 2012 – Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major primary liver cancers in adults. The phenotypic overlap between HCC and CC has been shown to comprise a continuous liver cancer spectrum.

High‐mobility group box 1 activates caspase‐1 and promotes hepatocellular carcinoma invasiveness and metastases

Wei Yan, Ying Chang, Xiaoyan Liang, Jon S. Cardinal, Hai Huang, Stephen H. Thorne, Satdarshan P.S. Monga, David A. Geller, Michael T. Lotze, Allan Tsung – 11 January 2012 – Hypoxia is often found in solid tumors and is associated with tumor progression and poor clinical outcomes. The exact mechanisms related to hypoxia‐induced invasion and metastasis remain unclear.

Combined effects of different interleukin‐28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection

Janett Fischer, Stephan Böhm, Markus Scholz, Tobias Müller, Heiko Witt, Jacob George, Christoph Sarrazin, Simone Susser, Eckart Schott, Vijayaprakash Suppiah, David R. Booth, Graeme J. Stewart, Florian van Bömmel, Annika Brodzinski, Balazs Fülöp, Pascal Migaud, Thomas Berg – 11 January 2012 – In patients with chronic hepatitis C virus (HCV) infection, several variants of the interleukin‐28B (IL28B) gene have been shown to correlate significantly with a sustained virologic response (SVR).

Risk factors and outcomes of failed endoscopic retrograde cholangiopancreatography in liver transplant recipients with anastomotic biliary strictures: A case‐control study

Domingo Balderramo, Oriol Sendino, Marta Burrel, Maria Isabel Real, Annabel Blasi, Graciela Martinez‐Palli, Josep M. Bordas, Juan Carlos Garcia‐Valdecasas, Antoni Rimola, Miguel Navasa, Josep Llach, Andres Cardenas – 4 January 2012 – Anastomotic strictures (ASs) of the biliary duct after liver transplantation (LT) are primarily managed with endoscopic retrograde cholangiopancreatography (ERCP), but in some cases, this fails because of difficulties in passing the strictures.

Mortality associated with carbapenem‐resistant Klebsiella pneumoniae infections in liver transplant recipients

Jayant S. Kalpoe, Edith Sonnenberg, Stephanie H. Factor, Juan del Rio Martin, Thomas Schiano, Gopi Patel, Shirish Huprikar – 4 January 2012 – Resistant bacterial infections are important causes of morbidity and mortality after liver transplantation (LT). This was a retrospective cohort study evaluating the outcomes associated with carbapenem‐resistant Klebsiella pneumoniae (CRKP) infections after LT. In a 2005‐2006 cohort of 175 consecutive LT recipients, 91 infection episodes were observed in 61 patients (35%). The mortality rate 1 year after LT was 18% (32/175).

Effects of ethnicity and socioeconomic status on survival and severity of fibrosis in liver transplant recipients with hepatitis C virus

Elizabeth C. Verna, Rosa Valadao, Erica Farrand, Elsa M. Pichardo, Jennifer C. Lai, Norah A. Terrault, Robert S. Brown – 4 January 2012 – The ethnicity and socioeconomic status of the host may affect the progression of hepatitis C virus (HCV). We aimed to compare survival and fibrosis progression in Hispanic white (HW) and non‐Hispanic white (NHW) recipients of liver transplantation (LT) with HCV. All HW and NHW patients with HCV who underwent transplantation between January 2000 and December 2007 at 2 centers were retrospectively assessed.

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