Sh(i)pping signals protect against Stat3‐driven liver cancer
Yulia A. Nevzorova, Christian Liedtke – 21 December 2011
Direct conversion of mouse fibroblasts to hepatocyte‐like cells using forced expression of endodermal transcription factors
E. Scott Swenson – 21 December 2011
Sorafenib in clinical practice: Evidence‐based use or abuse?
Michele Basso, Maria Basso, Carlo Barone – 21 December 2011
Sharpen your look on liver progenitor cells
Laurent Dollé, Konrad L. Streetz, Leo A. van Grunsven – 21 December 2011
A cell‐permeable hairpin peptide inhibits hepatitis C viral nonstructural protein 5A–mediated translation and virus production
Ronik Khachatoorian, Vaithilingaraja Arumugaswami, Piotr Ruchala, Santanu Raychaudhuri, Eden M. Maloney, Edna Miao, Asim Dasgupta, Samuel W. French – 20 December 2011 – NS5A is a key regulator of the hepatitis C virus (HCV) life cycle including RNA replication, assembly, and translation. We and others have shown that NS5A augments HCV internal ribosomal entry site (IRES)‐mediated translation. Furthermore, Quercetin treatment and heat shock protein (HSP) 70 knockdown inhibit the NS5A‐driven augmentation of IRES‐mediated translation and infectious virus production.
Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study
Paul C. Adams, Mark Speechley, James C. Barton, Christine E. McLaren, Gordon D. McLaren, John H. Eckfeldt – 20 December 2011 – Hemochromatosis is considered by many to be an uncommon disorder, although the prevalence of HFE (High Iron) 282 Cys → Tyr (C282Y) homozygosity is relatively high in Caucasians. Liver disease is one of the most consistent findings in advanced iron overload resulting from hemochromatosis. Liver clinics are often thought to be ideal venues for diagnosis of hemochromatosis, but diagnosis rates are often low.
Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: A prospective study
Javier Fernández, Juan Acevedo, Miriam Castro, Orlando Garcia, Carlos Rodríguez de Lope, Daria Roca, Marco Pavesi, Elsa Sola, Leticia Moreira, Anibal Silva, Tiago Seva‐Pereira, Francesco Corradi, Jose Mensa, Pere Ginès, Vicente Arroyo – 20 December 2011 – Epidemiology, risk factors, and clinical effect of infections by multiresistant bacteria in cirrhosis are poorly known. This work was a prospective evaluation in two series of cirrhotic patients admitted with infection or developing infection during hospitalization.
Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
Romina Lomonaco, Carolina Ortiz‐Lopez, Beverly Orsak, Amy Webb, Jean Hardies, Celia Darland, Joan Finch, Amalia Gastaldelli, Stephen Harrison, Fermin Tio, Kenneth Cusi – 20 December 2011 – The role of adipose tissue insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear.
Outcomes of curative treatment for hepatocellular cancer in nonalcoholic steatohepatitis versus hepatitis C and alcoholic liver disease
Srinevas K. Reddy, Jennifer L. Steel, Hui‐Wei Chen, David J. DeMateo, Jon Cardinal, Jaideep Behari, Abhinav Humar, J. Wallis Marsh, David A. Geller, Allan Tsung – 20 December 2011 – Concomitant increasing incidences of hepatocellular carcinoma (HCC) and nonalcoholic steatohepatitis (NASH) suggest that a substantial proportion of HCC arises as a result of hepatocellular injury from NASH.