AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function

Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Sotaro Naoi, Reiko Horikawa, Hironori Nagasaka, Tomozumi Takatani, Tamio Fukushima, Asami Hattori, Takashi Yabuki, Ikuo Horii, Yuichi Sugiyama – 19 January 2012 – The bile salt export pump (BSEP) mediates the biliary excretion of bile salts and its dysfunction induces intrahepatic cholestasis. Reduced canalicular expression of BSEP resulting from the promotion of its internalization is one of the causes of this disease state. However, the molecular mechanism underlying BSEP internalization from the canalicular membrane (CM) remains unknown.

Liver transplantation in septuagenarians receiving model for end‐stage liver disease exception points for hepatocellular carcinoma: The national experience

Jason J. Schwartz, Lisa Pappas, Heather F. Thiesset, Gabriela Vargas, John B. Sorensen, Robin D. Kim, William R. Hutson, Kenneth Boucher, Terry Box – 17 January 2012 – Current liver allocation policy in the United States grants liver transplant candidates with stage T2 hepatocellular carcinoma (HCC) a priority Model for End‐Stage Liver Disease (MELD) score of 22, regardless of age.

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