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Philip Starkey Lewis, James Dear, Vivien Platt, Jonathan Moggs, Chris Goldring, B. Kevin Park – 27 December 2011
Phytosterol and cholesterol precursor levels indicate increased cholesterol excretion and biosynthesis in gallstone disease
Marcin Krawczyk, Dieter Lütjohann, Ramin Schirin‐Sokhan, Luis Villarroel, Flavio Nervi, Fernando Pimentel, Frank Lammert, Juan Francisco Miquel – 27 December 2011 – In hepatocytes and enterocytes sterol uptake and secretion is mediated by Niemann‐Pick C1‐like 1 (NPC1L1) and ATP‐binding cassette (ABC)G5/8 proteins, respectively. Whereas serum levels of phytosterols represent surrogate markers for intestinal cholesterol absorption, cholesterol precursors reflect cholesterol biosynthesis.
Awareness of infection, knowledge of hepatitis C, and medical follow‐up among individuals testing positive for hepatitis C: National Health and Nutrition Examination Survey 2001‐2008
Maxine M. Denniston, R. Monina Klevens, Geraldine M. McQuillan, Ruth B. Jiles – 27 December 2011 – Many persons infected with hepatitis C virus (HCV) are unknown to the healthcare system because they may be asymptomatic for years, have not been tested for HCV infection, and only seek medical care when they develop liver‐related complications. We analyzed data from persons who tested positive for past or current HCV infection during participation in the National Health and Nutrition Examination Survey (NHANES) from 2001 through 2008.
Cognitive dysfunction in cirrhosis is associated with falls: A prospective study
Germán Soriano, Eva Román, Joan Córdoba, Maria Torrens, Maria Poca, Xavier Torras, Càndid Villanueva, Ignasi J. Gich, Víctor Vargas, Carlos Guarner – 27 December 2011 – Falls are frequent among patients with debilitating disorders and can have a serious effect on health status. Mild cognitive disturbances associated with cirrhosis may increase the risk for falls. Identifying subjects at risk may allow the implementation of preventive measures. Our aim was to assess the predictive value of the Psychometric Hepatic Encephalopathy Score (PHES) in identifying patients likely to sustain falls.
An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish
Liangliang Xu, Wenguang Yin, Jianhong Xia, Meixiu Peng, Song Li, Shuo Lin, Duanqing Pei, Xiaodong Shu – 27 December 2011
Identification of endogenous normalizers for serum MicroRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer
Ruiqun Qi, Matthew Weiland, Xing‐Hua Gao, Li Zhou, Qing‐Sheng Mi – 27 December 2011
Effect of interleukin‐28B on treatment outcome in hepatitis C virus G1/4 patients receiving response‐guided therapy with pegylated interferon alpha‐2a/ribavirin
Brian L. Pearlman, Carole Ehleben – 27 December 2011
Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP‐ribose) polymerases
Jun‐Xiang Zhang, Da‐Qiang Li, Aiwu Ruth He, Mona Motwani, Vasilis Vasiliou, Jeyanthy Eswaran, Lopa Mishra, Rakesh Kumar – 27 December 2011 – Hepatocellular carcinoma (HCC) is a particularly lethal form of cancer, yet effective therapeutic options for advanced HCC are limited. The poly(ADP‐ribose) polymerases (PARPs) and histone deacetylases (HDACs) are emerging to be among the most promising targets in cancer therapy, and sensitivity to PARP inhibition depends on homologous recombination (HR) deficiency and inhibition of HDAC activity blocks the HR pathway.
In Memoriam: Harold O. Conn, M.D.
James L. Boyer, Guadalupe Garcia‐Tsao, Roberto J. Groszmann – 27 December 2011
Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways
Qiang Chen, Wenjiao Li, Yunyan Wan, Xiaochun Xia, Qiao Wu, Yanling Chen, Zhide Lai, Chundong Yu, Wengang Li – 27 December 2011 – Transcriptional coactivator amplified in breast cancer 1 (AIB1) plays important roles in the progression of several cancers such as prostate cancer, breast cancer, and hepatocellular carcinoma. However, its role in cholangiocarcinoma (CCA), a chemoresistant bile duct carcinoma with a poor prognosis, remains unclear. In this study we found that AIB1 protein was frequently overexpressed in human CCA specimens and CCA cell lines.