| AASLD

Cyclin G1–mediated epithelial‐mesenchymal transition via phosphoinositide 3‐kinase/Akt signaling facilitates liver cancer progression

Read more about Cyclin G1–mediated epithelial‐mesenchymal transition via phosphoinositide 3‐kinase/Akt signaling facilitates liver cancer progression

Wen Wen, Jin Ding, Wen Sun, Jing Fu, Yao Chen, Kun Wu, Beifang Ning, Tao Han, Lei Huang, Cheng Chen, Dong Xie, Zhong Li, Gensheng Feng, Mengchao Wu, Weifen Xie, Hongyang Wang – 23 January 2012 – Cyclin G1 deficiency is associated with reduced incidence of carcinogen‐induced hepatocellular carcinoma (HCC), but its function in HCC progression remains obscure. We report a critical role of cyclin G1 in HCC metastasis. Elevated expression of cyclin G1 was detected in HCCs (60.6%), and its expression levels were even higher in portal vein tumor thrombus.

Impact of hepatitis B virus (HBV) preS/S genomic variability on HBV surface antigen and HBV DNA serum levels

Read more about Impact of hepatitis B virus (HBV) preS/S genomic variability on HBV surface antigen and HBV DNA serum levels

Teresa Pollicino, Giuliana Amaddeo, Agnese Restuccia, Giuseppina Raffa, Angela Alibrandi, Giuseppina Cutroneo, Angelo Favaloro, Sergio Maimone, Giovanni Squadrito, Giovanni Raimondo – 23 January 2012 – To evaluate whether hepatitis B virus (HBV) preS/S gene variability has any impact on serum hepatitis B surface antigen (HBsAg) levels and to analyze the replication capacity of naturally occurring preS/S variants, sera from 40 untreated patients with HBV‐related chronic liver disease (hepatitis B e antigen [HBeAg]‐positive, n = 11; HBeAg‐negative, n = 29) were virologically characterized.

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function

Read more about AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function

Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Sotaro Naoi, Reiko Horikawa, Hironori Nagasaka, Tomozumi Takatani, Tamio Fukushima, Asami Hattori, Takashi Yabuki, Ikuo Horii, Yuichi Sugiyama – 19 January 2012 – The bile salt export pump (BSEP) mediates the biliary excretion of bile salts and its dysfunction induces intrahepatic cholestasis. Reduced canalicular expression of BSEP resulting from the promotion of its internalization is one of the causes of this disease state. However, the molecular mechanism underlying BSEP internalization from the canalicular membrane (CM) remains unknown.