Maria Lauda Tomasi, Ivan Tomasi, Komal Ramani, Rosa Maria Pascale, Jun Xu, Pasquale Giordano, José M. Mato, Shelly C. Lu – 10 March 2012 – Ubiquitin‐conjugating enzyme 9 (Ubc9) is required for sumoylation and is overexpressed in several malignancies, but its expression in hepatocellular carcinoma (HCC) is unknown. Hepatic S‐adenosyl methionine (SAMe) levels decrease in methionine adenosyltransferase 1A (Mat1a) knockout (KO) mice, which develop HCC, and in ethanol‐fed mice.

Eddy Kao, Masao Shinohara, Min Feng, Mo Yin Lau, Cheng Ji – 10 March 2012 – A portion of human immunodeficiency virus (HIV)‐infected patients undergoing protease inhibitor (PI) therapy concomitantly consume or abuse alcohol leading to hepatic injury. The underling mechanisms are not known. We hypothesize that HIV PIs aggravate alcohol‐induced liver injury through an endoplasmic reticulum (ER) stress mechanism. To address this, we treated mice, primary mouse hepatocytes (PMHs), and primary human hepatocytes (PHHs) with alcohol and the HIV PIs ritonavir (RIT) and lopinavir (LOP).

Alison B. Jazwinski, Andrew J. Muir – 6 March 2012 – Watch the interview with the authors

Stevan A. Gonzalez, Gary L. Davis – 6 March 2012 – Watch the interview with the authors

Stevan A. Gonzalez, Gary L. Davis – 6 March 2012 – Watch the interview with the authors

Saurabh Agrawal, Paul Y. Kwo – 6 March 2012 – Watch the interview with the authors

Andrew Aronsohn, Donald Jensen – 6 March 2012 – Watch the interview with the authors

Saurabh Agrawal, Paul Y. Kwo – 6 March 2012 – Watch the interview with the authors

Naveen Gara, Marc G. Ghany – 6 March 2012 – Watch the interview with the authors

Doris B. Strader, Leonard B. Seeff – 6 March 2012 – Watch the interview with the authors