Caroline Scholtes, Christophe Ramière, Dominique Rainteau, Laure Perrin‐Cocon, Claude Wolf, Lydie Humbert, Martine Carreras, Aurélie Guironnet‐Paquet, Fabien Zoulim, Ralf Bartenschlager, Vincent Lotteau, Patrice André, Olivier Diaz – 30 January 2012 – Hepatitis C virus (HCV) particles associate viral and lipoprotein moieties to form hybrid lipoviral particles (LVPs). Cell culture–produced HCV (HCVcc) and ex vivo–characterized LVPs primarily differ by their apolipoprotein (apo) B content, which is low for HCVcc, but high for LVPs.

Kenichi Harada, Shinji Shimoda, Yasushi Kimura, Yasunori Sato, Hiroko Ikeda, Saya Igarashi, Xiang‐Shan Ren, Hirohide Sato, Yasuni Nakanuma – 30 January 2012 – IgG4 reactions consisting of marked infiltration by immunoglobulin G4 (IgG4)‐positive plasma cells in affected organs is found in cancer patients as well as patients with IgG4‐related diseases. Notably, extrahepatic cholangiocarcinomas accompanying marked IgG4 reactions clinicopathologically mimic IgG4‐related sclerosing cholangitis.

Jae‐Hwi Jang, Andreas Rickenbacher, Bostjan Humar, Achim Weber, Dimitri Aristotle Raptis, Kuno Lehmann, Bruno Stieger, Wolfgang Moritz, Christopher Soll, Panco Georgiev, David Fischer, Endre Laczko, Rolf Graf, Pierre‐Alain Clavien – 30 January 2012 – Obstructive cholestasis induces liver injury, postoperative complications, and mortality after surgery. Adaptive control of cholestasis, including bile salt homeostasis, is necessary for recovery and survival. Peripheral serotonin is a cytoprotective neurotransmitter also associated with liver regeneration.

30 January 2012

Evangelos Cholongitas, Andrew K. Burroughs – 30 January 2012

Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez – 30 January 2012 – Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can develop into cirrhosis, hepatic failure, and hepatocellular carcinoma. Although several metabolic pathways are disrupted and endogenous metabolites may change in NASH, the alterations in serum metabolites during NASH development remain unclear.

Kirsty Boyd, Barbara Kimbell, Scott Murray, John Iredale – 30 January 2012

Kenneth S. H. Chok, James Y. Y. Fung, See Ching Chan, Tan To Cheung, William W. Sharr, Albert C. Y. Chan, Sheung Tat Fan, Chung Mau Lo – 30 January 2012 – This study investigated the outcomes of living donor liver transplantation (LDLT) for patients with preoperative type 1 hepatorenal syndrome (HRS) and acute hepatic decompensation. Prospectively collected data for 104 patients who had fulminant hepatic failure, acute decompensation of cirrhosis, or an acute flare of chronic hepatitis B were analyzed.

Gin‐Ho Lo – 30 January 2012

Hui‐Chun Huang, Sun‐Sang Wang, I‐Fang Hsin, Ching‐Chih Chang, Fa‐Yauh Lee, Han‐Chieh Lin, Chiao‐Lin Chuang, Jing‐Yi Lee, Hsian‐Guey Hsieh, Shou‐Dong Lee – 30 January 2012 – Angiogenesis in liver cirrhosis leads to splanchnic hyperemia, increased portal inflow, and portosystemic collaterals formation, which may induce lethal complications, such as gastroesophageal variceal hemorrhage and hepatic encephalopathy. Cannabinoids (CBs) inhibit angiogenesis, but the relevant influences in cirrhosis are unknown.