Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma

Naoshi Nishida, Masatoshi Kudo, Takeshi Nagasaka, Iwao Ikai, Ajay Goel – 12 March 2012 – We aimed to identify the specific subset of tumor suppressor genes (TSGs) that are methylation‐silenced during the earliest steps of hepatocarcinogenesis, and to further evaluate whether these genes can serve as predictive biomarkers of hepatocellular carcinoma (HCC) emergence.

Early bedside detection of ischemia and rejection in liver transplants by microdialysis

Håkon Haugaa, Ebbe B. Thorgersen, Anne Pharo, Kirsten M. Boberg, Aksel Foss, Pål Dag Line, Truls Sanengen, Runar Almaas, Guro Grindheim, Soeren Erik Pischke, Tom Eirik Mollnes, Tor Inge Tønnessen – 12 March 2012 – This study was performed to explore whether lactate, pyruvate, glucose, and glycerol levels sampled via microdialysis catheters in the transplanted liver could be used to detect ischemia and/or rejection. The metabolites were measured at the bedside every 1 to 2 hours after the operation for a median of 10 days.

Anesthesia for liver transplantation in US academic centers: Institutional structure and perioperative care

Ann Walia, M. Susan Mandell, Nathaniel Mercaldo, Damon Michaels, Amy Robertson, Arna Banerjee, Ramachander Pai, John Klinck, Matthew Weinger, Pratik Pandharipande, Roman Schumann – 12 March 2012 – Investigators at a single institution have shown that the organization of the anesthesia team influences patient outcomes after liver transplant surgery. Little is known about how liver transplant anesthesiologists are organized to deliver care throughout the United States.

S‐adenosyl methionine regulates ubiquitin‐conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers

Maria Lauda Tomasi, Ivan Tomasi, Komal Ramani, Rosa Maria Pascale, Jun Xu, Pasquale Giordano, José M. Mato, Shelly C. Lu – 10 March 2012 – Ubiquitin‐conjugating enzyme 9 (Ubc9) is required for sumoylation and is overexpressed in several malignancies, but its expression in hepatocellular carcinoma (HCC) is unknown. Hepatic S‐adenosyl methionine (SAMe) levels decrease in methionine adenosyltransferase 1A (Mat1a) knockout (KO) mice, which develop HCC, and in ethanol‐fed mice.

Subscribe to