George A. Diaz, Lauren S. Krivitzky, Masoud Mokhtarani, William Rhead, James Bartley, Annette Feigenbaum, Nicola Longo, William Berquist, Susan A. Berry, Renata Gallagher, Uta Lichter‐Konecki, Dennis Bartholomew, Cary O. Harding, Stephen Cederbaum, Shawn E. McCandless, Wendy Smith, Gerald Vockley, Stephen A. Bart, Mark S. Korson, David Kronn, Roberto Zori, J. Lawrence Merritt, Sandesh C.S. Nagamani, Joseph Mauney, Cynthia LeMons, Klara Dickinson, Tristen L. Moors, Dion F. Coakley, Bruce F.

George A. Diaz, Lauren S. Krivitzky, Masoud Mokhtarani, William Rhead, James Bartley, Annette Feigenbaum, Nicola Longo, William Berquist, Susan A. Berry, Renata Gallagher, Uta Lichter‐Konecki, Dennis Bartholomew, Cary O. Harding, Stephen Cederbaum, Shawn E. McCandless, Wendy Smith, Gerald Vockley, Stephen A. Bart, Mark S. Korson, David Kronn, Roberto Zori, J. Lawrence Merritt, Sandesh C.S. Nagamani, Joseph Mauney, Cynthia LeMons, Klara Dickinson, Tristen L. Moors, Dion F. Coakley, Bruce F.

Valentina Medici, Noreene M. Shibata, Kusum K. Kharbanda, Janine M. LaSalle, Rima Woods, Sarah Liu, Jesse A. Engelberg, Sridevi Devaraj, Natalie J. Török, Joy X. Jiang, Peter J. Havel, Bo Lönnerdal, Kyoungmi Kim, Charles H. Halsted – 4 September 2012 – Hepatic methionine metabolism may play an essential role in regulating methylation status and liver injury in Wilson's disease (WD) through the inhibition of S‐adenosylhomocysteine hydrolase (SAHH) by copper (Cu) and the consequent accumulation of S‐adenosylhomocysteine (SAH).

Kari Nejak‐Bowen, Alexander Kikuchi, Satdarshan P.S. Monga – 3 September 2012 – Wnt/β‐catenin signaling plays an important role in hepatic homeostasis, especially in liver development, regeneration, and cancer, and loss of β‐catenin signaling is often associated with increased apoptosis. To elucidate how β‐catenin may be regulating hepatocyte survival, we investigated the susceptibility of β‐catenin conditional knockout (KO) mice and their wild‐type (WT) littermates to Fas and tumor necrosis factor‐α (TNF‐α), two common pathways of hepatocyte apoptosis.

Frank K. Huynh, Ursula H. Neumann, Ying Wang, Brian Rodrigues, Timothy J. Kieffer, Scott D. Covey – 3 September 2012 – Obesity is highly associated with dyslipidemia and cardiovascular disease. However, the mechanism behind this association is not completely understood. The hormone leptin may be a molecular link between obesity and dysregulation of lipid metabolism. Leptin can affect lipid metabolism independent of its well‐known effects on food intake and energy expenditure, but exactly how this occurs is ill‐defined.

Nedim Hadžić – 3 September 2012

Tai‐Chung Tseng, Chun‐Jen Liu, Hung‐Chih Yang, Tung‐Hung Su, Chia‐Chi Wang, Chi‐Ling Chen, Cheng‐An Hsu, Stephanie Fang‐Tzu Kuo, Chen‐Hua Liu, Pei‐Jer Chen, Ding‐Shinn Chen, Jia‐Horng Kao – 3 September 2012 – Chronic hepatitis B patients with high viral loads are at increased risk of cirrhosis and hepatocellular carcinoma (HCC). In patients with low viral loads, higher hepatitis B surface antigen (HBsAg) levels have been shown to predict HCC development.

Marcela Aparicio‐Vergara, Pascal P.H. Hommelberg, Marijke Schreurs, Nanda Gruben, Rinke Stienstra, Ronit Shiri‐Sverdlov, Niels J. Kloosterhuis, Alain de Bruin, Bart van de Sluis, Debby P.Y. Koonen, Marten H. Hofker – 3 September 2012 – Ectodomain shedding of tumor necrosis factor receptor 1 (TNFR1) provides negative feedback to the inflammatory loop induced by TNFα.

Marianne Samyn – 1 September 2012 – Key Points

Christoph R. Werner, Daniel P. Egetemeyr, Ulrich M. Lauer, Silvio Nadalin, Alfred Königsrainer, Nisar P. Malek, Christoph P. Berg – 1 September 2012 – After liver transplantation (LT), the management of recurrent hepatitis C virus (HCV) infections still remains a major challenge. In HCV genotype 1 patients not undergoing transplantation, the introduction of protease inhibitor (PI)–based regimens has increased the sustained virological response rate significantly.