Anna Albecka, Sandrine Belouzard, Anne Op de Beeck, Véronique Descamps, Lucie Goueslain, Justine Bertrand‐Michel, François Tercé, Gilles Duverlie, Yves Rouillé, Jean Dubuisson – 26 November 2011 – Hepatitis C virus (HCV) particles are known to be in complex with lipoproteins. As a result of this interaction, the low‐density lipoprotein (LDL) receptor (LDLR) has been proposed as a potential entry factor for HCV; however, its implication in virus entry remains unclear.

David B. Rein, Gretchen A. Stevens, Jordan Theaker, John S. Wittenborn, Steven T. Wiersma – 26 November 2011 – We estimated the global burden of hepatitis E virus (HEV) genotypes 1 and 2 in 2005. HEV is an emergent waterborne infection that causes source‐originated epidemics of acute disease with a case fatality rate thought to vary by age and pregnancy status.

Michael H. Nathanson – 26 November 2011

Bharath Nath, Gyongyi Szabo – 26 November 2011 – Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology.

Karim C. El Kasmi, Aimee L. Anderson, Michael W. Devereaux, Sophie A. Fillon, J. Kirk Harris, Mark A. Lovell, Milton J. Finegold, Ronald J. Sokol – 26 November 2011 – Infants with intestinal failure who are parenteral nutrition (PN)‐dependent may develop cholestatic liver injury and cirrhosis (PN‐associated liver injury: PNALI). The pathogenesis of PNALI remains incompletely understood.

Irani Khatun, Sebastian Zeissig, Jahangir Iqbal, Minghui Wang, David Curiel, Gregory S. Shelness, Richard S. Blumberg, M.Mahmood Hussain – 26 November 2011 – Microsomal triglyceride transfer protein (MTP), essential for apolipoprotein B (apoB) biosynthesis, evolved as a phospholipid transfer protein and acquired triglyceride transfer activity during a transition from invertebrates to vertebrates. But it is unknown whether MTP directly transfers lipids onto apoB in vivo and, if it does, whether both neutral and polar lipid transfer activities of MTP are critical for lipoprotein assembly.

Young Chul Kim, Mi‐Suk Park – 26 November 2011

Young Chul Kim, Mi‐Suk Park – 26 November 2011

Jeremy S. Duffield – 26 November 2011

Liping Liu, Govardhana Rao Yannam, Taichiro Nishikawa, Toshiyuki Yamamoto, Hesham Basma, Ryotaro Ito, Masaki Nagaya, Joyeeta Dutta‐Moscato, Donna B. Stolz, Fenghai Duan, Klaus H. Kaestner, Yoram Vodovotz, Alejandro Soto‐Gutierrez, Ira J. Fox – 23 November 2011 – In advanced cirrhosis, impaired function is caused by intrinsic damage to the native liver cells and from the abnormal microenvironment in which the cells reside. The extent to which each plays a role in liver failure and regeneration is unknown.