Use of living donor liver transplantation varies with the availability of deceased donor liver transplantation

Parsia A. Vagefi, Nancy L. Ascher, Chris E. Freise, Jennifer L. Dodge, John P. Roberts – 17 October 2011 – The demographics of patients in the United States who undergo living donor liver transplantation (LDLT) versus patients who undergo deceased donor liver transplantation (DDLT) are interesting with respect to the demographics of the donor service areas (DSAs). We examined adult recipients of primary, non–status 1 liver‐only transplants from 2003 to 2009. The likelihood of undergoing LDLT was compared to the likelihood of undergoing DDLT by multivariate logistic regression.

Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation

Benjamin H. Friedman, Joshua H. Wolf, Liqing Wang, Mary E. Putt, Abraham Shaked, Jason D. Christie, Wayne W. Hancock, Kim M. Olthoff – 17 October 2011 – Early allograft dysfunction (EAD) occurring in the first week post‐liver transplantation is associated with increased graft failure and mortality and is believed to be largely due to ischemia/reperfusion injury.

Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid

Masanobu Tsuda, Yuki Moritoki, Zhe‐Xiong Lian, Weici Zhang, Katsunori Yoshida, Kanji Wakabayashi, Guo‐Xiang Yang, Toshio Nakatani, John Vierling, Keith Lindor, M. Eric Gershwin, Christopher L. Bowlus – 17 October 2011 – The aim of this study was to determine the safety and potential efficacy of B‐cell depletion with the anti‐CD20 monoclonal antibody rituximab in patients with primary biliary cirrhosis (PBC) and an incomplete response to ursodeoxycholic acid (UDCA).

A phase 2, randomized, double‐blind, placebo‐controlled study of GS‐9450 in subjects with nonalcoholic steatohepatitis

Vlad Ratziu, Muhammad Y. Sheikh, Arun J. Sanyal, Joseph K. Lim, Hari Conjeevaram, Naga Chalasani, Manal Abdelmalek, Anezi Bakken, Christophe Renou, Melissa Palmer, Robert A. Levine, B. Raj Bhandari, Melanie Cornpropst, Wei Liang, Benjamin King, Elsa Mondou, Franck S. Rousseau, John McHutchison, Mario Chojkier – 17 October 2011 – In nonalcoholic steatohepatitis (NASH), the extent of hepatocyte apoptosis correlates with disease severity. Reducing hepatocyte apoptosis with the selective caspase inhibitor GS‐9450 has a potential for altering the course of the liver disease.

Accuracy and disagreement of computed tomography and magnetic resonance imaging for the diagnosis of small hepatocellular carcinoma and dysplastic nodules: Role of biopsy

Thomas Sersté, Vincent Barrau, Violaine Ozenne, Marie‐Pierre Vullierme, Pierre Bedossa, Olivier Farges, Dominique‐Charles Valla, Valérie Vilgrain, Valérie Paradis, Françoise Degos – 17 October 2011 – Liver macronodules, ranging from benign to low‐grade or high‐grade dysplastic nodules (LGDNs/HGDNs) and hepatocellular carcinoma (HCC), may develop during chronic liver diseases (CLDs).

Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells

Chen‐Hsin Liao, Chau‐Ting Yeh, Ya‐Hui Huang, Sheng‐Ming Wu, Hsiang‐Cheng Chi, Ming‐Ming Tsai, Chung‐Ying Tsai, Chia‐Jung Liao, Yi‐Hsin Tseng, Yang‐Hsiang Lin, Cheng‐Yi Chen, I‐Hsiao Chung, Wan‐Li Cheng, Wei‐Jan Chen, Kwang‐Huei Lin – 12 October 2011 – Thyroid hormone (T3) mediates cellular growth, development, and differentiation by binding to the nuclear thyroid hormone receptor (TR). Recent studies suggest that long‐term hypothyroidism is associated with human hepatocellular carcinoma (HCC) independent from other major HCC risk factors.

Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll‐like receptor activation

Christian L. Roth, Clinton T. Elfers, Dianne P. Figlewicz, Susan J. Melhorn, Gregory J. Morton, Andrew Hoofnagle, Matthew M. Yeh, James E. Nelson, Kris V. Kowdley – 12 October 2011 – Childhood obesity is associated with type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD). Recent studies have found associations between vitamin D deficiency (VDD), insulin resistance (IR), and NAFLD among overweight children.

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