Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing

Diana Vetter, Michal Cohen‐Naftaly, Augusto Villanueva, Youngmin A. Lee, Peri Kocabayoglu, Rebekka Hannivoort, Goutham Narla, Josep M. Llovet, Swan N. Thung, Scott L. Friedman – 26 April 2012 – KLF6‐SV1 (SV1), the major splice variant of KLF6, antagonizes the KLF6 tumor suppressor by an unknown mechanism. Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown.

Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice

Johan M. Waern, Qinggong Yuan, Urda Rüdrich, Pablo D. Becker, Kai Schulze, Helene Strick‐Marchand, Nicholas D. Huntington, Behrend J. Zacher, Karsten Wursthorn, James P. DiSanto, Carlos A. Guzman, Michael P. Manns, Michael Ott, Michael Bock – 26 April 2012 – Macrophages play an important role in the rejection of xenogeneic cells and therefore represent a major obstacle to generating chimeric mice with human xenografts that are useful tools for basic and preclinical medical research.

LecT‐hepa, a glyco‐marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients

Kiyoaki Ito, Atsushi Kuno, Yuzuru Ikehara, Masaya Sugiyama, Hiroaki Saito, Yoshihiko Aoki, Teppei Matsui, Masatoshi Imamura, Masaaki Korenaga, Kazumoto Murata, Naohiko Masaki, Yasuhito Tanaka, Shuhei Hige, Namiki Izumi, Masayuki Kurosaki, Shuhei Nishiguchi, Michiie Sakamoto, Masayoshi Kage, Hisashi Narimatsu, Masashi Mizokami – 26 April 2012 – Assessment of liver fibrosis in patients with chronic hepatitis C (CHC) is critical for predicting disease progression and determining future antiviral therapy.

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