Upper limits of normal for alanine aminotransferase activity in the United States population

Constance E. Ruhl, James E. Everhart – 10 October 2011 – Alanine aminotransferase (ALT) is an important test for liver disease, yet there is no generally accepted upper limit of normal (ULN) in the United States. Furthermore, the ability of ALT to differentiate persons with and without liver disease is uncertain. We examined cut‐offs for ALT for their ability to discriminate between persons with positive hepatitis C virus (HCV) RNA and those at low risk for liver injury in the U.S. population. Among adult participants in the 1999‐2008 U.S.

Validation of the donor risk index in orthotopic liver transplantation within the Eurotransplant region

Joris J. Blok, Andries E. Braat, Rene Adam, Andrew K. Burroughs, Hein Putter, Nigel G. Kooreman, Axel O. Rahmel, Robert J. Porte, Xavier Rogiers, Jan Ringers, for the European Liver Intestine Transplant Association and the Eurotransplant Liver Intestine Advisory Committee – 10 October 2011 – In Eurotransplant, more than 50% of liver allografts come from extended criteria donors (ECDs). However, not every ECD is the same. The limits of their use are being explored.

Antagonism of peripheral hepatic cannabinoid receptor‐1 improves liver lipid metabolism in mice: Evidence from cultured explants

Tony Jourdan, Laurent Demizieux, Joseph Gresti, Louiza Djaouti, Lila Gaba, Bruno Vergès, Pascal Degrace – 10 October 2011 – It is well established that inactivation of the central endocannabinoid system (ECS) through antagonism of cannabinoid receptor 1 (CB1R) reduces food intake and improves several pathological features associated with obesity, such as dyslipidemia and liver steatosis. Nevertheless, recent data indicate that inactivation of peripheral CB1R could also be directly involved in the control of lipid metabolism independently of central CB1R.

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b–infected null responders

Kazuaki Chayama, Shoichi Takahashi, Joji Toyota, Yoshiyasu Karino, Kenji Ikeda, Hiroki Ishikawa, Hideaki Watanabe, Fiona McPhee, Eric Hughes, Hiromitsu Kumada – 10 October 2011 – Patients with chronic hepatitis C virus (HCV) infection and previous null response to pegylated interferon (Peg‐IFN) and ribavirin (RBV) have limited therapeutic options. HCV genotype 1 is the most common worldwide and the most difficult to treat; genotype 1b is the most common subtype of genotype 1 outside North America.

Impact of venous systemic oxygen persufflation supplemented with nitric oxide gas on cold‐stored, warm ischemia–damaged experimental liver grafts

Pramod Kadaba Srinivasan, Shintaro Yagi, Benedict Doorschodt, Kazuyuki Nagai, Mamdouh Afify, Shinji Uemoto, Rene Tolba – 10 October 2011 – The increasing shortage of donor organs has led to the increasing use of organs from non–heart‐beating donors. We aimed to assess the impact of venous systemic oxygen persufflation (VSOP) supplemented with nitric oxide (NO) gas during the cold storage (CS) of warm ischemia (WI)–damaged experimental liver grafts.

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