Is there still a role for liver biopsy in managing hepatitis C virus infections?
Syed‐Mohammed R. Jafri, Stuart C. Gordon – 26 April 2012 – Watch the interview with the authors
Importance of patient education and monitoring among HCV‐infected patients selected for anti‐viral treatment
Corinne Wentworth‐Kotara, P.A‐C. – 26 April 2012 – Watch the interview with the authors
Predicting the response to the treatment of hepatitis C virus infection
David L. Thomas – 26 April 2012 – Watch the interview with the authors
The prognosis of perihilar cholangiocarcinoma after radical treatments
Luca Fabris, Domenico Alvaro – 24 April 2012
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure
Pedro E. Marques, Sylvia S. Amaral, Daniele A. Pires, Laura L. Nogueira, Frederico M. Soriani, Braulio H.F. Lima, Gabriel A.O. Lopes, Remo C. Russo, Thiago V. Ávila, Juliana G. Melgaço, André G. Oliveira, Marcelo A. Pinto, Cristiano X. Lima, Ana Maria De Paula, Denise C. Cara, Maria F. Leite, Mauro M. Teixeira, Gustavo Batista Menezes – 24 April 2012 – Acetaminophen (APAP) is a safe analgesic and antipyretic drug. However, APAP overdose leads to massive hepatocyte death.
Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: Immunomodulation by the cAMP‐PKA pathway
Haofeng Ji, Yu Zhang, Xiu‐da Shen, Feng Gao, Cynthia Y. Huang, Catalina Abad, Ronald W. Busuttil, James A. Waschek, Jerzy W. Kupiec‐Weglinski – 24 April 2012 – Hepatic ischemia and reperfusion injury (IRI), an exogenous antigen‐independent local inflammation response, occurs in multiple clinical settings, including liver transplantation, hepatic resection, trauma, and shock. The immune system and the nervous system maintain extensive communication and mount a variety of integrated responses to danger signals through intricate chemical messengers.
Perils of the information highway: We need better road maps
Silvia Hafliger – 24 April 2012
Prophylaxis versus preemptive therapy for cytomegalovirus disease in high‐risk liver transplant recipients
Marta Bodro, Núria Sabé, Laura Lladó, Carme Baliellas, Jordi Niubó, Jose Castellote, Joan Fabregat, Antoni Rafecas, Jordi Carratalà – 24 April 2012 – Cytomegalovirus (CMV) infection is an opportunistic infection frequently found after solid organ transplantation, and it contributes significantly to mortality and morbidity. CMV‐seronegative recipients of grafts from CMV‐seropositive donors have the highest risk of CMV disease. The most appropriate strategy for preventing CMV disease in this population is a matter of active debate.
Specific bile acids inhibit hepatic fatty acid uptake in mice
Biao Nie, Hyo Min Park, Melissa Kazantzis, Min Lin, Amy Henkin, Stephanie Ng, Sujin Song, Yuli Chen, Heather Tran, Robin Lai, Chris Her, Jacquelyn J. Maher, Barry M. Forman, Andreas Stahl – 24 April 2012 – Bile acids are known to play important roles as detergents in the absorption of hydrophobic nutrients and as signaling molecules in the regulation of metabolism. We tested the novel hypothesis that naturally occurring bile acids interfere with protein‐mediated hepatic long chain free fatty acid (LCFA) uptake.
Von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis
Monika Ferlitsch, Thomas Reiberger, Matthias Hoke, Petra Salzl, Bernadette Schwengerer, Gregor Ulbrich, Berit Anna Payer, Michael Trauner, Markus Peck‐Radosavljevic, Arnulf Ferlitsch – 24 April 2012 – von Willebrand factor antigen (vWF‐Ag) is elevated in patients with liver cirrhosis, but the clinical significance is unclear. We hypothesized that vWF‐Ag levels may correlate with portal pressure, measured by hepatic venous pressure gradient (HVPG), and predict clinically significant portal hypertension (CSPH; HVPG ≥10 mmHg), decompensation and mortality.