Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats

Mar Coll, Sarai Rodriguez, Imma Raurell, Nahia Ezkurdia, Astrid Brull, Salvador Augustin, Jaime Guardia, Rafael Esteban, María Martell, Joan Genescà – 18 May 2012 – We aimed to evaluate the effects of droxidopa (an oral synthetic precursor of norepinephrine) on the hemodynamic and renal alterations of portal hypertensive rats. Sham, portal vein‐ligated (PVL), and 4‐week biliary duct‐ligated (BDL) rats received a single oral dose of droxidopa (25‐50 mg/kg) or vehicle and hemodynamic parameters were monitored for 2 hours.

The centrosomal protein tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin‐dependent kinase 2

Wai‐Lung Lai, Wing‐Yan Hung, Leo Lap‐Yan Wong, Yuan Zhou, Veronica Yee‐Law Leong, Joyce Man‐Fong Lee, Irene Oi‐Lin Ng, Dong‐Yan Jin, Yick‐Pang Ching – 18 May 2012 – Deregulation of cellular‐signaling pathways by the inactivation of tumor‐suppressor genes is one of the major causes of hepatocellular carcinoma (HCC). In this study, we identified Tax1 binding protein 2 (TAX1BP2) as a novel tumor‐suppressor gene in HCC.

Rare inborn errors associated with chronic hepatitis B virus infection*

Qiang Zhao, Liang Peng, Weijun Huang, Qibin Li, Yuanyuan Pei, Ping Yuan, Lingyan Zheng, Yongling Zhang, Jia Deng, Cheng Zhong, Bin Hu, Hongke Ding, Wei Fang, Ru Li, Qijun Liao, Chaoshuang Lin, Weiping Deng, Huijun Yan, Jinghui Hou, Qiuliang Wu, Tingting Xu, Jinsong Liu, Longbo Hu, Tao Peng, Suqing Chen, Kar N. Lai, Man‐Fung Yuen, Yue Wang, Mala K. Maini, Caixia Li, Miaoxin Li, Jian Wang, Xiuqing Zhang, Pak‐Chung Sham, Jun Wang, Zhi‐Liang Gao, Yiming Wang – 18 May 2012 – Chronic hepatitis B (CHB) is a major global health issue.

Outcomes after living donor liver transplantation for acute liver failure in Japan: Results of a nationwide survey

Noriyo Yamashiki, Yasuhiko Sugawara, Sumihito Tamura, Nobuaki Nakayama, Makoto Oketani, Koji Umeshita, Shinji Uemoto, Satoshi Mochida, Hirohito Tsubouchi, Norihiro Kokudo – 11 May 2012 – Nationwide surveys of acute liver failure (ALF) are conducted annually in Japan, and 20% of patients with ALF undergo liver transplantation (LT). We extracted data for 212 patients who underwent LT for ALF from the nationwide survey database of the Intractable Liver Diseases Study Group of Japan.

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