Histological discrimination between autoimmune hepatitis and drug‐induced liver injury
Keiichi Fujiwara, Osamu Yokosuka – 31 October 2011
The long and the short of interferon‐gamma–inducible protein 10 in hepatitis C virus infection
Mark D. Gorrell, Amany Zekry, Geoffrey W. McCaughan, Andrew Lloyd – 28 October 2011
Boceprevir (Victrelis) for HCV: V is for victory and very complex
Michael Charlton, Michael D. Leise – 28 October 2011
Exhausted or just sleeping: Awakening virus‐specific responses in chronic hepatitis C virus infection
Nicole A.W. Wood, May La Linn, David G. Bowen – 28 October 2011
Opening the door for hepatitis C virus infection in genetically humanized mice
Mirjam B. Zeisel, Daniel Da Costa, Thomas F. Baumert – 28 October 2011
Efficient human fetal liver cell isolation protocol based on vascular perfusion for liver cell–based therapy and case report on cell transplantation
Bruno Gridelli, Giovanni Vizzini, Giada Pietrosi, Angelo Luca, Marco Spada, Salvatore Gruttadauria, Davide Cintorino, Giandomenico Amico, Cinzia Chinnici, Toshio Miki, Eva Schmelzer, Pier Giulio Conaldi, Fabio Triolo, Jörg C. Gerlach – 27 October 2011 – Although hepatic cell transplantation (CT) holds the promise of bridging patients with end‐stage chronic liver failure to whole liver transplantation, suitable cell populations are under debate.
Of mice and men, calcineurin inhibitors and hepatitis C
Alleluiah Rutebemberwa, Hugo R. Rosen – 27 October 2011
Growth‐hormone–induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer
Katrin Friedbichler, Madeleine Themanns, Kristina M. Mueller, Michaela Schlederer, Jan‐Wilhelm Kornfeld, Luigi M. Terracciano, Andrey V. Kozlov, Susanne Haindl, Lukas Kenner, Thomas Kolbe, Mathias Mueller, Kenneth J. Snibson, Markus H. Heim, Richard Moriggl – 26 October 2011 – Persistently high levels of growth hormone (GH) can cause liver cancer. GH activates multiple signal‐transduction pathways, among them janus kinase (JAK) 2‐signal transducer and activator of transcription (STAT) 5 (signal transducer and activator of transcription 5).
Human liver cell spheroids in extended perfusion bioreactor culture for repeated‐dose drug testing
Rui M. Tostões, Sofia B. Leite, Margarida Serra, Janne Jensen, Petter Björquist, Manuel J. T. Carrondo, Catarina Brito, Paula M. Alves – 26 October 2011 – Primary cultures of human hepatocyte spheroids are a promising in vitro model for long‐term studies of hepatic metabolism and cytotoxicity. The lack of robust methodologies to culture cell spheroids, as well as a poor characterization of human hepatocyte spheroid architecture and liver‐specific functionality, have hampered a widespread adoption of this three‐dimensional culture format.
Hepatitis C virus reinfection and superinfection among treated and untreated participants with recent infection
Jason Grebely, Son Truong Pham, Gail V. Matthews, Kathy Petoumenos, Rowena A. Bull, Barbara Yeung, William Rawlinson, John Kaldor, Andrew Lloyd, Margaret Hellard, Gregory J. Dore, Peter A. White, on behalf of the ATAHC Study Group – 26 October 2011 – The purpose of the study was to evaluate reinfection and superinfection during treatment for recent hepatitis C virus (HCV). The Australian Trial in Acute Hepatitis C (ATAHC) was a prospective study of the natural history and treatment of recent HCV.