Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease

Vincent Wai‐Sun Wong, Julien Vergniol, Grace Lai‐Hung Wong, Juliette Foucher, Henry Lik‐Yuen Chan, Brigitte Le Bail, Paul Cheung‐Lung Choi, Mathurin Kowo, Anthony Wing‐Hung Chan, Wassil Merrouche, Joseph Jao‐Yiu Sung, Victor de Lédinghen – 25 January 2010 – Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in affluent countries. Accurate noninvasive tests for liver injury are urgently needed.

Huh‐7: A human “hemochromatotic” cell line

Chiara Vecchi, Giuliana Montosi, Antonello Pietrangelo – 25 January 2010 – Hereditary hemochromatosis (HC) is commonly associated with homozygosity for the cysteine‐to‐tyrosine substitution at position 282 (C282Y) of the HFE protein. This mutation prevents HFE from binding beta2‐microglobulin (beta2M) and reaching the cell surface. We have discovered that a widely used hepatoma cell line, Huh‐7, carries a HFE mutation similar to that associated with human HC. By HFE gene sequencing of Huh‐7 genomic DNA, we found a TAC nucleotide deletion (c.

Prognostic value of Ishak fibrosis stage: Findings from the hepatitis C antiviral long‐term treatment against cirrhosis trial

James E. Everhart, Elizabeth C. Wright, Zachary D. Goodman, Jules L. Dienstag, John C. Hoefs, David E. Kleiner, Marc G. Ghany, A. Scott Mills, S. Russell Nash, Sugantha Govindarajan, Thomas E. Rogers, Joel K. Greenson, Elizabeth M. Brunt, Herbert L. Bonkovsky, Chihiro Morishima, Heather J. Litman, HALT‐C Trial Group – 25 January 2010 – Studies of the prognostic value of Ishak fibrosis stage are lacking.

Increased model for end‐stage liver disease score at the time of liver transplant results in prolonged hospitalization and overall intensive care unit costs

Matthew R. Foxton, Mohammad A. B. Al‐Freah, Andrew J. Portal, Elizabeth Sizer, William Bernal, Georg Auzinger, Mohamed Rela, Julia A. Wendon, Nigel D. Heaton, John G. O'Grady, Michael A. Heneghan – 25 January 2010 – Organ allocation based on Model for End‐Stage Liver Disease (MELD) resulted in decreased waiting list mortality in the United States. However, reports suggest an increase in resource utilization as a consequence of this. The aim of this study is to assess the correlation of MELD at transplant with post–liver transplant (LT) intensive care unit (ICU) costs.

Hydrodynamics‐based transfection of plasmid encoding receptor activator for nuclear factor kappa B–Fc protects against hepatic ischemia/reperfusion injury in mice

Jian Shi, Wenyu Shao, Dongchang Yang, Liang Zhao, Lei Deng, Xuehao Wang, Beicheng Sun – 25 January 2010 – Hepatic ischemia/reperfusion (I/R) injury is very important in transplant surgery.

Integrated approach for the identification of human hepatocyte nuclear factor 4α target genes using protein binding microarrays

Eugene Bolotin, Hailing Liao, Tuong Chi Ta, Chuhu Yang, Wendy Hwang‐Verslues, Jane R. Evans, Tao Jiang, Frances M. Sladek – 25 January 2010 – Hepatocyte nuclear factor 4 alpha (HNF4α), a member of the nuclear receptor superfamily, is essential for liver function and is linked to several diseases including diabetes, hemophilia, atherosclerosis, and hepatitis. Although many DNA response elements and target genes have been identified for HNF4α, the complete repertoire of binding sites and target genes in the human genome is unknown.

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