Dina G. Tiniakos, George V. Papatheodoridis – 25 January 2010

Saul J. Karpen – 25 January 2010

Lingyi Zhang, Guqi Wang, Weihong Hou, Ping Li, Andrea Dulin, Herbert L. Bonkovsky – 25 January 2010 – Chronic hepatitis B (CHB) is major global health problem. In China, where about 120,000,000 persons are chronically infected, CHB has been treated for centuries with traditional Chinese medicines (TCMs). This review summarizes and meta‐analyzes the results of randomized controlled trials (RCTs) of TCM formulations reported in China in 1998‐2008 for treatment of CHB.

Laura Pelletier, Sandra Rebouissou, Alain Paris, Estelle Rathahao‐Paris, Elisabeth Perdu, Paulette Bioulac‐Sage, Sandrine Imbeaud, Jessica Zucman‐Rossi – 25 January 2010 – Hepatocellular adenomas (HCAs) are benign liver tumors that usually develop in women who are taking oral contraceptives. Among these tumors, biallelic inactivating mutations of the hepatocyte nuclear factor 1α (HNF1A) transcription factor have been frequently identified and in rare cases of hepatocellular carcinomas developed in noncirrhotic liver.

Diego Geroldi, Enzo Emanuele – 25 January 2010

Anna Ludovica Fracanzani, Alberto Piperno, Luca Valenti, Mirella Fraquelli, Sabina Coletti, Alessandra Maraschi, Dario Consonni, Enzo Coviello, Dario Conte, Silvia Fargion – 25 January 2010 – The clinical presentation of hereditary hemochromatosis has changed markedly in recent years. The aim of this study was to analyze a large series of consecutive Italian patients with hemochromatosis diagnosed between 1976 and 2007 to determine whether the genetic background and the presence of acquired risk factors influenced the severity of iron overload and the natural history of the disease.

Matt Cave, Keith Cameron Falkner, Mukunda Ray, Swati Joshi‐Barve, Guy Brock, Rehan Khan, Marjorie Bon Homme, Craig J. McClain – 25 January 2010 – Although nonalcoholic steatohepatitis (NASH) is typically associated with obesity, it has also been reported to occur in lean individuals exposed to industrial chemicals. Occupational exposure to vinyl chloride (VC) is a well‐documented risk factor for hemangiosarcoma, but has not previously been associated with steatohepatitis. Here we evaluate liver biopsies from 25 nonobese, highly exposed VC workers for steatohepatitis.

Vincent Wai‐Sun Wong, Julien Vergniol, Grace Lai‐Hung Wong, Juliette Foucher, Henry Lik‐Yuen Chan, Brigitte Le Bail, Paul Cheung‐Lung Choi, Mathurin Kowo, Anthony Wing‐Hung Chan, Wassil Merrouche, Joseph Jao‐Yiu Sung, Victor de Lédinghen – 25 January 2010 – Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in affluent countries. Accurate noninvasive tests for liver injury are urgently needed.

Roger Chapman, Johan Fevery, Anthony Kalloo, David M. Nagorney, Kirsten Muri Boberg, Benjamin Shneider, Gregory J. Gores – 25 January 2010

Chiara Vecchi, Giuliana Montosi, Antonello Pietrangelo – 25 January 2010 – Hereditary hemochromatosis (HC) is commonly associated with homozygosity for the cysteine‐to‐tyrosine substitution at position 282 (C282Y) of the HFE protein. This mutation prevents HFE from binding beta2‐microglobulin (beta2M) and reaching the cell surface. We have discovered that a widely used hepatoma cell line, Huh‐7, carries a HFE mutation similar to that associated with human HC. By HFE gene sequencing of Huh‐7 genomic DNA, we found a TAC nucleotide deletion (c.