Masato Fujiki, Carlos O. Esquivel, Olivia M. Martinez, Samuel Strober, Shinji Uemoto, Sheri M. Krams – 26 January 2010 – Posttransplant total lymphoid irradiation is a nonmyeloablative regimen that has been extensively studied in rodent models for the induction of tolerance to bone marrow and solid organ allografts. Previous studies of experimental models and clinical transplantation have used total lymphoid irradiation in combination with anti‐lymphocyte–depleting reagents and donor cell infusion to promote graft acceptance.

Nicholas A. Shackel, David G. Bowen, Geoffrey W. McCaughan – 26 January 2010

Donald J. Messner, Kris V. Kowdley – 26 January 2010

Norah Terrault, Mandana Khalili – 26 January 2010

Eleanor S. Gilchrist, John N. Plevris – 26 January 2010 – Hematopoietic stem cells have potential in the field of regenerative medicine because of their capacity to form cells of different lineages. Bone marrow stem cells have been shown to contribute to parenchymal liver cell populations, and although this may not be functionally significant, it has sparked interest in the field of autologous stem cell infusion as a possible treatment for cirrhosis.

Zhi Zhong, Shigeki Tsukada, Hasibur Rehman, Christopher J. Parsons, Tom P. Theruvath, Richard A. Rippe, David A. Brenner, John J. Lemasters – 26 January 2010 – Transforming growth factor‐β (TGF‐β) is a potent inhibitor of cell proliferation. This study investigated whether overexpression of Smad7, which blocks TGF‐β–induced activation of Smad2/3, could prevent the suppression of regeneration of small‐for‐size liver grafts. Rats were intravenously given adenoviruses (2 × 1010 pfu/rat) carrying the LacZ gene or the Smad7 gene (Ad‐Smad7) 3 days prior to liver harvesting.

Wei‐Ju Su, Ming‐Chih Ho, Yen‐Hsuan Ni, Jia‐Feng Wu, Yung‐Ming Jeng, Huey‐Ling Chen, Yao‐Ming Wu, Rey‐Heng Hu, Mei‐Hwei Chang, Po‐Huang Lee – 26 January 2010 – The characteristics of hepatitis B virus (HBV) in vaccinated children who acquire de novo HBV infections after orthotopic liver transplantation (OLT) remain largely unknown. The aim of this study was to explore HBV mutants in pediatric OLT recipients with de novo HBV infections.

26 January 2010

Thomas D. Schiano, Rosamond Rhodes – 26 January 2010 – Transplant programs are likely to encounter increasing numbers of patients who return after receiving an organ transplant abroad. These patients will require ongoing medical care to monitor their immunosuppression and to provide treatment when the need arises. Transplant societies have condemned transplantation with organs purchased abroad and with organs procured from executed prisoners in China.

Rajasekhar Tanikella, Steven M. Kawut, Robert S. Brown, Michael J. Krowka, Jenna Reinen, Chandrasekhar R. Dinasarapu, James F. Trotter, Kari E. Roberts, Mustafa A. Mohd, Donna K. Arnett, Michael B. Fallon – 26 January 2010 – Health‐related quality of life (HRQOL) is an important measure of the effects of chronic liver disease in affected patients that helps guide interventions to improve well‐being. However, the relationship between HRQOL and survival in liver transplant candidates remains unclear.