From liver markers to life expectancy
Chia‐Chi Wang, Jia‐Horng Kao – 25 January 2010
The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response
Elisabeth Lehmann, Walid Hamdy El‐Tantawy, Matthias Ocker, Ralf Bartenschlager, Volker Lohmann, Said Hashemolhosseini, Gisa Tiegs, Gabriele Sass – 25 January 2010 – The anti‐inflammatory and antiapoptotic heme degrading enzyme heme oxygenase‐1 (HO‐1) has been shown recently to interfere with replication of hepatitis C virus (HCV). We investigated the effect of HO‐1 products carbon monoxide (CO), iron and biliverdin on HCV replication using the replicon cell lines Huh‐5‐15 and LucUbiNeo‐ET, stably expressing HCV proteins NS3 through NS5B.
Carvedilol versus variceal band ligation for prevention of the first variceal bleed
Chia‐Chi Wang, Jia‐Horng Kao – 25 January 2010
Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events
Craig Lammert, Einar Bjornsson, Anna Niklasson, Naga Chalasani – 25 January 2010 – Reactive metabolites generated by hepatic metabolism are thought to play an important role in the pathogenesis of drug‐induced liver injury (DILI), but supporting data are limited. If this is true, then compounds with significant hepatic metabolism should cause more DILI than those without it. We conducted a study to examine the relationship between hepatic metabolism and DILI of prescription medications.
Decreased survival of subjects with elevated liver function tests during a 28‐year follow‐up
Cecilia Söderberg, Per Stål, Johan Askling, Hans Glaumann, Greger Lindberg, Joel Marmur, Rolf Hultcrantz – 25 January 2010 – The long‐term survival of subjects with nonalcoholic fatty liver disease (NAFLD) in comparison with both individuals with elevated transaminases attributable to other causes and the general poulation is poorly characterized.
The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell–derived endoderm
Atsushi Kubo, Yon Hui Kim, Stefan Irion, Shogo Kasuda, Mitsuaki Takeuchi, Kazuo Ohashi, Masayuki Iwano, Yoshiko Dohi, Yoshihiko Saito, Ralph Snodgrass, Gordon Keller – 25 January 2010 – We investigated the role of the hematopoietically expressed homeobox (Hex) in the differentiation and development of hepatocytes within embryonic stem cell (ESC)–derived embryoid bodies (EBs). Analyses of hepatic endoderm derived from Hex−/− EBs revealed a dramatic reduction in the levels of albumin (Alb) and alpha‐fetoprotein (Afp) expression.
Noninvasive assessment of liver disease severity with liver fat score and CK‐18 in NAFLD: Prognostic value of liver fat equation goes beyond hepatic fat estimation
Giovanni Musso, Roberto Gambino, Marilena Durazzo, Maurizio Cassader – 25 January 2010
Tolvaptan and hyponatremia in a patient with cirrhosis
Thomas D. Boyer – 25 January 2010
Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg‐positive chronic hepatitis B
Hyun Woong Lee, Heon Ju Lee, Jae Seok Hwang, Joo Hyun Sohn, Jae Young Jang, Ki Jun Han, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Yong Han Paik, Chun Kyon Lee, Kwan Sik Lee, Chae Yoon Chon, Kwang‐Hyub Han – 25 January 2010 – The reported durability of virologic response after successful lamivudine monotherapy is variable, and the question remains as to whether virologic responses can be maintained over an extended follow‐up period.