Late reuse of liver allografts from brain‐dead graft recipients: The Munich experience and a review of the literature

Markus Rentsch, Jens Meyer, Joachim Andrassy, Carl‐Ludwig Fischer‐Fröhlich, Christan Rust, Susanna Mueller, Martin Angele, Florian Löhe, Karl‐Walter Jauch, Christian Graeb – 1 March 2010 – The increasing donor organ shortage requires the consideration of any possible organ donor in order to meet the current demand. However, the growing number of long‐term survivors of liver transplantation may create a situation in which former organ recipients may experience brain death with a functioning graft and therefore become organ donors themselves.

Comparison of calibrated and uncalibrated arterial pressure–based cardiac output monitors during orthotopic liver transplantation

Vladimir Krejci, Andrea Vannucci, Alhan Abbas, William Chapman, Ivan M. Kangrga – 1 March 2010 – Arterial pressure–based cardiac output monitors (APCOs) are increasingly used as alternatives to thermodilution. Validation of these evolving technologies in high‐risk surgery is still ongoing. In liver transplantation, FloTrac‐Vigileo (Edwards Lifesciences) has limited correlation with thermodilution, whereas LiDCO Plus (LiDCO Ltd.) has not been tested intraoperatively.

Portal pressure <15 mm Hg is a key for successful adult living donor liver transplantation utilizing smaller grafts than before

Yasuhiro Ogura, Tomohide Hori, Walid M. El Moghazy, Atsushi Yoshizawa, Fumitaka Oike, Akira Mori, Toshimi Kaido, Yasutsugu Takada, Shinji Uemoto – 1 March 2010 – To prevent small‐for‐size syndrome in adult‐to‐adult living donor liver transplantation (A‐LDLT), larger grafts (ie, right lobe grafts) have been selected in many transplant centers. However, some centers are investigating the benefits of portal pressure modulation. Five hundred sixty‐six A‐LDLT procedures using right or left lobe grafts were performed between 1998 and 2008.

Institute of Medicine recommendations for the prevention and control of hepatitis B and C

Abigail E. Mitchell, Heather M. Colvin, R. Palmer Beasley – 22 February 2010 – Despite federal, state, and local public health efforts to prevent and control hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, these diseases remain serious health problems in the United States. About 1%‐2% of the U.S. population has chronic HBV or HCV infections, and each year about 15,000 people die from liver cancer or liver disease related to these preventable infections.

Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation

Ali Raza, George Dikdan, Kunj K. Desai, Asif Shareef, Helen Fernandes, Virginie Aris, Andrew N. de la Torre, Dorian Wilson, Adrian Fisher, Patricia Soteropoulos, Baburao Koneru – 19 February 2010 – The benefits of ischemic preconditioning (IPC) in reducing ischemia/reperfusion injury (IRI) remain indistinct in human liver transplantation (LT). To further understand mechanistic aspects of IPC, we performed microarray analyses as a nested substudy in a randomized trial of 10‐minute IPC in 101 deceased donor LTs.

Prognostic factors affecting survival after recurrence in adult living donor liver transplantation for hepatocellular carcinoma

Woo Young Shin, Kyung‐Suk Suh, Hae Won Lee, Joohyun Kim, Taehoon Kim, Nam‐Joon Yi, Kuhn Uk Lee – 12 February 2010 – Liver transplantation is regarded as an effective treatment for early hepatocellular carcinoma (HCC). However, some patients experience recurrence and subsequently rapid progression of the disease. We investigated prognostic factors affecting survival after recurrence in patients who underwent adult living donor liver transplantation (LDLT) for HCC. From October 1992 to December 2005, 138 adult patients underwent LDLT for HCC.

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