Ann M. Thomas, Steven N. Hart, Bo Kong, Jianwen Fang, Xiao‐bo Zhong, Grace L. Guo – 26 March 2010 – Farnesoid X receptor (FXR) is a bile acid‐activated transcription factor belonging to the nuclear receptor superfamily. FXR is highly expressed in liver and intestine and crosstalk mediated by FXR in these two organs is critical in maintaining bile acid homeostasis. FXR deficiency has been implicated in many liver and intestine diseases. However, regulation of transcription by FXR at the genomic level is not known.

Christopher Soll, Jae Hwi Jang, Marc‐Oliver Riener, Wolfgang Moritz, Peter Johannes Wild, Rolf Graf, Pierre‐Alain Clavien – 26 March 2010 – In addition to its function as a neurotransmitter and vascular active molecule, serotonin is also a mitogen for hepatocytes and promotes liver regeneration. A possible role in hepatocellular cancer has not yet been investigated. Human hepatocellular cancer cell lines Huh7 and HepG2 were used to assess the function of serotonin in these cell lines.

Da‐Wei Zhang, Huijie Bian – 26 March 2010

Agustin Castiella, Eva Zapata, Pedro Otazua, Leire Zubiaurre, Javier Fernandez – 26 March 2010

Dirk Stabenow, Marianne Frings, Christina Trück, Katja Gärtner, Irmgard Förster, Christian Kurts, Thomas Tüting, Margarete Odenthal, Hans‐Peter Dienes, Karin Cederbrant, Ulrike Protzer, Percy A. Knolle – 26 March 2010 – In vivo evaluation of CD8 T cell effector (cytotoxic T lymphocyte [CTL]) function in peripheral organs such as the liver is currently not possible but would greatly improve our understanding of local immune regulation, because simple determination of antigen‐specific CTL numbers does not predict the outcome of immune responses.

George B. McDonald – 26 March 2010

Philipp J. Jost, Thomas Kaufmann – 26 March 2010

Achim Weber, Regina Boger, Binje Vick, Toni Urbanik, Johannes Haybaeck, Stefan Zoller, Andreas Teufel, Peter H. Krammer, Joseph T. Opferman, Peter R. Galle, Marcus Schuchmann, Mathias Heikenwalder, Henning Schulze‐Bergkamen – 26 March 2010 – Regulation of hepatocellular apoptosis is crucial for liver homeostasis. Increased sensitivity of hepatocytes toward apoptosis results in chronic liver injury, whereas apoptosis resistance is linked to hepatocarcinogenesis and nonresponsiveness to therapy‐induced cell death.

Gustav Paumgartner – 26 March 2010 – A review is presented of Gustav Paumgartner's five decades of research and practice in hepatology focusing on biliary physiology and disease. It begins with studies of the excretory function of the liver including hepatic uptake of indocyanine green, bilirubin, and bile acids. The implications of these studies for diagnosis and understanding of liver diseases are pointed out. From there, the path of scientific research leads to investigations of hepatobiliary bile acid transport and the major mechanisms of bile formation.

Leander Blaas, Jan‐Wilhelm Kornfeld, Daniel Schramek, Monica Musteanu, Gernot Zollner, Judith Gumhold, Franziska van Zijl, Doris Schneller, Harald Esterbauer, Gerda Egger, Markus Mair, Lukas Kenner, Wolfgang Mikulits, Robert Eferl, Richard Moriggl, Josef Penninger, Michael Trauner, Emilio Casanova – 26 March 2010 – Growth hormone (GH) resistance and low serum levels of insulinlike growth factor 1 (IGF‐1) are common features in human liver fibrosis and cirrhosis.