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Thierry Gustot, Richard Moreau – 26 March 2010
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Ina Bergheim, Astrid Spruss – 26 March 2010
Mitogen‐inducible gene‐6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma
Markus Reschke, Ingvar Ferby, Ewa Stepniak, Nina Seitzer, David Horst, Erwin F. Wagner, Axel Ullrich – 26 March 2010 – The mitogen‐inducible gene‐6 (mig‐6) is a multi‐adaptor protein implicated in the regulation of the HER family of receptor tyrosine kinases. We have reported recently that mig‐6 is a negative regulator of epidermal growth factor receptor (EGFR)‐dependent skin morphogenesis and tumor formation in vivo. In the liver, ablation of mig‐6 leads to an increase in EGFR protein levels, suggesting that mig‐6 is a negative regulator of EGFR function.
Importance of the compensatory anti‐inflammatory response following severe sepsis on cirrhosis
Philip A. Berry, Charalambos G. Antoniades, Julia Wendon – 26 March 2010
The link between hepatosteatosis and cells of the immune system
Anna Alisi, Nadia Panera, Valerio Nobili – 26 March 2010
Inhibition of mammalian target of rapamycin: The janus face of immunosuppression?
Christopher Soll, Pierre‐Alain Clavien – 26 March 2010
Sirolimus‐based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma
Christian Toso, Shaheed Merani, David L. Bigam, A.M. James Shapiro, Norman M. Kneteman – 26 March 2010 – Liver transplantation is an important treatment option for selected patients with nonresectable hepatocellular carcinoma (HCC). Several reports have suggested a lower risk of posttransplant tumor recurrence with the use of sirolimus and a higher one with calcineurin inhibitors, but the selection of an ideal immunosuppression protocol is still a matter of debate.
Nucleotide‐binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis
Beate Appenrodt, Frank Grünhage, Martin G. Gentemann, Lydia Thyssen, Tilman Sauerbruch, Frank Lammert – 26 March 2010 – Spontaneous bacterial peritonitis (SBP), a severe complication in patients with advanced liver cirrhosis, has been attributed to bacterial translocation from the intestine. Variants of the NOD2 (nucleotide‐binding oligomerization domain containing 2) gene have been associated with impaired mucosal barrier function in Crohn disease. We hypothesized that the risk of acquiring SBP is increased in patients with cirrhosis carrying NOD2 variants.
The emerging role of T cell immunoglobulin mucin‐1 in the mechanism of liver ischemia and reperfusion injury in the mouse
Yoichiro Uchida, Bibo Ke, Maria Cecilia S. Freitas, Haofeng Ji, Danyun Zhao, Elizabeth R. Benjamin, Nader Najafian, Hideo Yagita, Hisaya Akiba, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 26 March 2010 – The T cell immunoglobulin and mucin domain‐containing molecules (TIM) protein family, which is expressed by T cells, plays a crucial role in regulating host adaptive immunity and tolerance. However, its role in local inflammation, such as innate immunity‐dominated organ ischemia–reperfusion injury (IRI), remains unknown.
HFE C282Y homozygotes are at increased risk of breast and colorectal cancer
Nicholas J. Osborne, Lyle C. Gurrin, Katrina J. Allen, Clare C. Constantine, Martin B. Delatycki, Christine E. McLaren, Dorota M. Gertig, Gregory J. Anderson, Melissa C. Southey, John K. Olynyk, Lawrie W. Powell, John L. Hopper, Graham G. Giles, Dallas R. English – 26 March 2010 – The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Melbourne Collaborative Cohort Study is a prospective cohort study that commenced recruitment in 1990.