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Kojiro Taura, Kouichi Miura, David Brenner – 26 March 2010
Portal fibroblasts: Underappreciated mediators of biliary fibrosis
Jonathan A. Dranoff, Rebecca G. Wells – 26 March 2010 – Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the setting of chronic injury to fibrogenic myofibroblasts, playing an important role in collagen production in the fibrotic liver. Portal fibroblasts (PFs) are located adjacent to bile duct epithelia and thus play a particularly significant role in biliary fibrosis.
Twelve weeks posttreatment follow‐up is as relevant as 24 weeks to determine the sustained virologic response in patients with hepatitis C virus receiving pegylated interferon and ribavirin
Michelle Martinot‐Peignoux, Christiane Stern, Sarah Maylin, Marie‐Pierre Ripault, Nathalie Boyer, Laurence Leclere, Corinne Castelnau, Nathalie Giuily, Ahmed El Ray, Ana‐Carolina Cardoso, Rami Moucari, Tarik Asselah, Patrick Marcellin – 26 March 2010 – A sustained virologic response (SVR) in patients with chronic hepatitis C receiving pegylated interferon (PEG‐IFN) plus ribavirin is defined as undetectable serum HCV‐RNA at 24 weeks (W+24) posttreatment follow‐up. Viral load outcome in patients with virological relapse (VR) has not been explored.
Sorafenib inhibits the shedding of major histocompatibility complex class I–related chain A on hepatocellular carcinoma cells by down‐regulating a disintegrin and metalloproteinase 9
Keisuke Kohga, Tetsuo Takehara, Tomohide Tatsumi, Hisashi Ishida, Takuya Miyagi, Atsushi Hosui, Norio Hayashi – 26 March 2010 – The ectodomain of major histocompatibility complex class I–related chain A (MICA) is shed from tumor cells, and may be an important means of evading antitumor immunity. This study investigated the roles of a disintegrin and metalloproteinase 9 (ADAM9) in the shedding of MICA in human hepatocellular carcinoma (HCC).
Hepatic resection versus radiofrequency ablation for very early stage hepatocellular carcinoma: A Markov model analysis
Yun Ku Cho, Jae Kyun Kim, Wan Tae Kim, Jin Wook Chung – 26 March 2010 – No adequate randomized trials have been reported for a comparison between hepatic resection (HR) versus radiofrequency ablation (RFA) for the treatment of patients with very early stage hepatocellular carcinoma (HCC), defined as an asymptomatic solitary HCC <2 cm.
Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis
Guadalupe Garcia‐Tsao, Scott Friedman, John Iredale, Massimo Pinzani – 26 March 2010
Madelung's disease and alcoholic liver disorder
Mei‐Ju Ko, Hsien‐Ching Chiu – 26 March 2010
A missing link in the puzzle: Brown adipose tissue
Tugrul Purnak, Ersan Ozaslan, Cumali Efe, Hasan Sevimler – 26 March 2010
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Justin H. Nguyen – 26 March 2010
The anti‐inflammatory effects of adiponectin are mediated via a heme oxygenase‐1–dependent pathway in rat Kupffer cells
Palash Mandal, Pil‐Hoon Park, Megan R. McMullen, Brian T. Pratt, Laura E. Nagy – 26 March 2010 – Altered expression and activity of immunomodulatory cytokines plays a major role in the pathogenesis of alcoholic liver disease. Chronic ethanol feeding increases the sensitivity of Kupffer cells, the resident hepatic macrophage, to lipopolysaccharide (LPS), leading to increased tumor necrosis factor alpha (TNF‐α) expression. This sensitization is normalized by treatment of primary cultures of Kupffer cells with adiponectin, an anti‐inflammatory adipokine.