Interferon‐lambda genotype and low serum low‐density lipoprotein cholesterol levels in patients with chronic hepatitis C infection

Josephine H. Li, Xiang Qian Lao, Hans L. Tillmann, Jennifer Rowell, Keyur Patel, Alexander Thompson, Sunil Suchindran, Andrew J. Muir, John R. Guyton, Stephen D. Gardner, John G. McHutchison, Jeanette J. McCarthy – 23 May 2010 – Recently, genetic polymorphisms occurring in the interferon (IFN)‐lambda gene region were associated with response to IFN‐based treatment of hepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to IFN.

Intrahepatic peripheral cholangiocarcinoma in cirrhosis patients may display a vascular pattern similar to hepatocellular carcinoma on contrast‐enhanced ultrasound

Ramón Vilana, Alejandro Forner, Luis Bianchi, Ángeles García‐Criado, Jordi Rimola, Carlos Rodríguez de Lope, María Reig, Carmen Ayuso, Concepció Brú, Jordi Bruix – 23 May 2010 – The aim of this study was to describe the imaging features by contrast‐enhanced ultrasound (CEUS) of intrahepatic cholangiocarcinoma (ICC) in cirrhosis patients. We registered the CEUS images of cirrhosis patients with histologically confirmed ICC. In all cases magnetic resonance imaging (MRI) was done to confirm the diagnosis and/or staging purposes.

Hepatitis B virus replication in primary macaque hepatocytes: Crossing the species barrier toward a new small primate model

Julie Lucifora, Isabelle E. Vincent, Pascale Berthillon, Tatiana Dupinay, Maud Michelet, Ulrike Protzer, Fabien Zoulim, David Durantel, Christian Trepo, Isabelle Chemin – 23 May 2010 – The development of new anti–hepatitis B virus (HBV) therapies, especially immunotherapeutic approaches, has been limited by the lack of a primate model more accessible than chimpanzees. We have previously demonstrated that sylvanus and cynomolgus macaques are susceptible to in vivo HBV infection after intrahepatic HBV DNA inoculation.

Primary hepatocyte culture supports hepatitis C virus replication: A model for infection‐associated hepatocarcinogenesis

Krishna Banaudha, Jan M. Orenstein, Tamara Korolnek, Georges C. St. Laurent, Takaji Wakita, Ajit Kumar – 23 May 2010 – Analysis of progressive changes in hepatic gene expression that underlie hepatocarcinogenesis following hepatitis C virus (HCV) infection require examination of long‐term cultures of normally differentiating primary human hepatocytes. We report a culture system of primary hepatocytes that support productive replication of infectious HCV.

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