Hepatocyte‐specific deletion of the antiapoptotic protein myeloid cell leukemia‐1 triggers proliferation and hepatocarcinogenesis in mice

Achim Weber, Regina Boger, Binje Vick, Toni Urbanik, Johannes Haybaeck, Stefan Zoller, Andreas Teufel, Peter H. Krammer, Joseph T. Opferman, Peter R. Galle, Marcus Schuchmann, Mathias Heikenwalder, Henning Schulze‐Bergkamen – 26 March 2010 – Regulation of hepatocellular apoptosis is crucial for liver homeostasis. Increased sensitivity of hepatocytes toward apoptosis results in chronic liver injury, whereas apoptosis resistance is linked to hepatocarcinogenesis and nonresponsiveness to therapy‐induced cell death.

Biliary physiology and disease: Reflections of a physician‐scientist

Gustav Paumgartner – 26 March 2010 – A review is presented of Gustav Paumgartner's five decades of research and practice in hepatology focusing on biliary physiology and disease. It begins with studies of the excretory function of the liver including hepatic uptake of indocyanine green, bilirubin, and bile acids. The implications of these studies for diagnosis and understanding of liver diseases are pointed out. From there, the path of scientific research leads to investigations of hepatobiliary bile acid transport and the major mechanisms of bile formation.

Disruption of the growth hormone—Signal transducer and activator of transcription 5—Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis

Leander Blaas, Jan‐Wilhelm Kornfeld, Daniel Schramek, Monica Musteanu, Gernot Zollner, Judith Gumhold, Franziska van Zijl, Doris Schneller, Harald Esterbauer, Gerda Egger, Markus Mair, Lukas Kenner, Wolfgang Mikulits, Robert Eferl, Richard Moriggl, Josef Penninger, Michael Trauner, Emilio Casanova – 26 March 2010 – Growth hormone (GH) resistance and low serum levels of insulinlike growth factor 1 (IGF‐1) are common features in human liver fibrosis and cirrhosis.

Role of transforming growth factor β signaling and expansion of progenitor cells in regenerating liver

Arun Thenappan, Ying Li, Krit Kitisin, Asif Rashid, Kirti Shetty, Lynt Johnson, Lopa Mishra – 26 March 2010 – Adult hepatic progenitor cells are activated during regeneration when hepatocytes and bile duct epithelium are damaged or unable to proliferate. On the basis of its role as a tumor suppressor and in the potential malignant transformation of stem cells in hepatocellular carcinoma, we investigated the role of key transforming growth factor beta (TGF‐β) signaling components, including the Smad3 adaptor protein β2‐Spectrin (β2SP), in liver regeneration.

T‐Tube or no T‐tube in the reconstruction of the biliary tract during orthotopic liver transplantation: Systematic review and meta‐analysis

Carina Riediger, Michael W. Müller, Christoph W. Michalski, Norbert Hüser, Tibor Schuster, Jörg Kleeff, Helmut Friess – 23 March 2010 – The routine use of a T‐tube in reconstruction of the biliary tree during orthotopic liver transplantation (OLT) is controversial. A systematic review of the literature on the use of a T‐tube in reconstruction of the biliary tree was performed. Retrospective studies were only reviewed, whereas prospective randomized studies were included in the meta‐analysis. An analysis of 196 studies revealed that 91 studies investigated the use of a T‐tube in OLT.

Timing of hepatitis C antiviral therapy in patients with advanced liver disease: A decision analysis model

Sammy Saab, Douglas R. Hunt, Michael A. Stone, Amy McClune, Myron J. Tong – 23 March 2010 – Antiviral therapy for the treatment of hepatitis C virus (HCV) infection is used before and after liver transplantation. The objective of this study was to determine the most cost‐effective timing for pegylated interferon/ribavirin therapy in patients with advanced liver disease infected with genotype 1 HCV.

Subscribe to