Paired donor interchange to avoid ABO‐incompatible living donor liver transplantation

See Ching Chan, Chung Mau Lo, Boon Hun Yong, Wilson J. C. Tsui, Kelvin K. C. Ng, Sheung Tat Fan – 29 March 2010 – We report an emergency paired donor interchange living donor liver transplant performed on January 13, 2009. The 4 operations (2 liver transplants) were performed simultaneously. The aim was to avoid 2 ABO‐incompatible liver transplants. One recipient in acute liver failure underwent transplantation in a high‐urgency situation.

Role of transforming growth factor β signaling and expansion of progenitor cells in regenerating liver

Arun Thenappan, Ying Li, Krit Kitisin, Asif Rashid, Kirti Shetty, Lynt Johnson, Lopa Mishra – 26 March 2010 – Adult hepatic progenitor cells are activated during regeneration when hepatocytes and bile duct epithelium are damaged or unable to proliferate. On the basis of its role as a tumor suppressor and in the potential malignant transformation of stem cells in hepatocellular carcinoma, we investigated the role of key transforming growth factor beta (TGF‐β) signaling components, including the Smad3 adaptor protein β2‐Spectrin (β2SP), in liver regeneration.

Disruption of the growth hormone—Signal transducer and activator of transcription 5—Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis

Leander Blaas, Jan‐Wilhelm Kornfeld, Daniel Schramek, Monica Musteanu, Gernot Zollner, Judith Gumhold, Franziska van Zijl, Doris Schneller, Harald Esterbauer, Gerda Egger, Markus Mair, Lukas Kenner, Wolfgang Mikulits, Robert Eferl, Richard Moriggl, Josef Penninger, Michael Trauner, Emilio Casanova – 26 March 2010 – Growth hormone (GH) resistance and low serum levels of insulinlike growth factor 1 (IGF‐1) are common features in human liver fibrosis and cirrhosis.

Biliary physiology and disease: Reflections of a physician‐scientist

Gustav Paumgartner – 26 March 2010 – A review is presented of Gustav Paumgartner's five decades of research and practice in hepatology focusing on biliary physiology and disease. It begins with studies of the excretory function of the liver including hepatic uptake of indocyanine green, bilirubin, and bile acids. The implications of these studies for diagnosis and understanding of liver diseases are pointed out. From there, the path of scientific research leads to investigations of hepatobiliary bile acid transport and the major mechanisms of bile formation.

Hepatocyte‐specific deletion of the antiapoptotic protein myeloid cell leukemia‐1 triggers proliferation and hepatocarcinogenesis in mice

Achim Weber, Regina Boger, Binje Vick, Toni Urbanik, Johannes Haybaeck, Stefan Zoller, Andreas Teufel, Peter H. Krammer, Joseph T. Opferman, Peter R. Galle, Marcus Schuchmann, Mathias Heikenwalder, Henning Schulze‐Bergkamen – 26 March 2010 – Regulation of hepatocellular apoptosis is crucial for liver homeostasis. Increased sensitivity of hepatocytes toward apoptosis results in chronic liver injury, whereas apoptosis resistance is linked to hepatocarcinogenesis and nonresponsiveness to therapy‐induced cell death.

Bioluminescence imaging allows measuring CD8 T cell function in the liver

Dirk Stabenow, Marianne Frings, Christina Trück, Katja Gärtner, Irmgard Förster, Christian Kurts, Thomas Tüting, Margarete Odenthal, Hans‐Peter Dienes, Karin Cederbrant, Ulrike Protzer, Percy A. Knolle – 26 March 2010 – In vivo evaluation of CD8 T cell effector (cytotoxic T lymphocyte [CTL]) function in peripheral organs such as the liver is currently not possible but would greatly improve our understanding of local immune regulation, because simple determination of antigen‐specific CTL numbers does not predict the outcome of immune responses.

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