Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis

Pascal Lapierre, Kathie Béland, Caroline Martin, Fernando Alvarez, Fernando Alvarez – 22 April 2010 – Autoimmune hepatitis (AIH), like many autoimmune diseases, is most prevalent in young women. The immunological basis of this age and sex susceptibility bias was investigated in a murine model of AIH. Xenoimmunization of 7‐week‐old female C57BL/6 mice resulted in more severe AIH with higher levels of liver inflammation, serum alanine aminotransferase, specific T‐cell cytotoxicity, and autoantibody than younger and older females.

Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice

Begoña Ochoa, Wing‐Kin Syn, Igotz Delgado, Gamze F. Karaca, Youngmi Jung, Jiangbo Wang, Ana M. Zubiaga, Olatz Fresnedo, Alessia Omenetti, Marzena Zdanowicz, Steve S. Choi, Anna Mae Diehl – 22 April 2010 – Distinct mechanisms are believed to regulate growth of the liver during fetal development and after injury in adults, because the former relies on progenitors and the latter generally involves replication of mature hepatocytes.

Determination of immune memory to hepatitis B vaccination through early booster response in college students

Chyi‐Feng Jan, Kuo‐Chin Huang, Yin‐Chu Chien, Donald E. Greydanus, H. Dele Davies, Tai‐Yuan Chiu, Li‐Min Huang, Chien‐Jen Chen, Ding‐Shinn Chen – 22 April 2010 – The long‐term protection of hepatitis B (HB) vaccination has been debated for years. The purpose here was to evaluate the kinetic changes of antibody to HB surface antigen (anti‐HBs) and define immune memory of the HB vaccine among college students who had previously received full neonatal immunization against HB.

Characterization of the middle hepatic artery and its relevance to living donor liver transplantation

Shaofa Wang, Xiaoshun He, Ziping Li, Zhenpeng Peng, Nga Lei Tam, Canhui Sun, Anbin Hu, Jiefu Huang – 13 April 2010 – In comparison with the left and right hepatic arteries, there is a relative lack of information on the middle hepatic artery (MHA). In this study, data obtained by multidetector computed tomography from 145 patients were studied to evaluate anatomical variations of the MHA, a hilar artery that primarily supplies hepatic segment 4. An MHA was present in 103 (71%) of the subjects.

Paired donor interchange to avoid ABO‐incompatible living donor liver transplantation

See Ching Chan, Chung Mau Lo, Boon Hun Yong, Wilson J. C. Tsui, Kelvin K. C. Ng, Sheung Tat Fan – 29 March 2010 – We report an emergency paired donor interchange living donor liver transplant performed on January 13, 2009. The 4 operations (2 liver transplants) were performed simultaneously. The aim was to avoid 2 ABO‐incompatible liver transplants. One recipient in acute liver failure underwent transplantation in a high‐urgency situation.

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