Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis
Pascal Lapierre, Kathie Béland, Caroline Martin, Fernando Alvarez, Fernando Alvarez – 22 April 2010 – Autoimmune hepatitis (AIH), like many autoimmune diseases, is most prevalent in young women. The immunological basis of this age and sex susceptibility bias was investigated in a murine model of AIH. Xenoimmunization of 7‐week‐old female C57BL/6 mice resulted in more severe AIH with higher levels of liver inflammation, serum alanine aminotransferase, specific T‐cell cytotoxicity, and autoantibody than younger and older females.