Characterization of the middle hepatic artery and its relevance to living donor liver transplantation

Shaofa Wang, Xiaoshun He, Ziping Li, Zhenpeng Peng, Nga Lei Tam, Canhui Sun, Anbin Hu, Jiefu Huang – 13 April 2010 – In comparison with the left and right hepatic arteries, there is a relative lack of information on the middle hepatic artery (MHA). In this study, data obtained by multidetector computed tomography from 145 patients were studied to evaluate anatomical variations of the MHA, a hilar artery that primarily supplies hepatic segment 4. An MHA was present in 103 (71%) of the subjects.

Paired donor interchange to avoid ABO‐incompatible living donor liver transplantation

See Ching Chan, Chung Mau Lo, Boon Hun Yong, Wilson J. C. Tsui, Kelvin K. C. Ng, Sheung Tat Fan – 29 March 2010 – We report an emergency paired donor interchange living donor liver transplant performed on January 13, 2009. The 4 operations (2 liver transplants) were performed simultaneously. The aim was to avoid 2 ABO‐incompatible liver transplants. One recipient in acute liver failure underwent transplantation in a high‐urgency situation.

The anti‐inflammatory effects of adiponectin are mediated via a heme oxygenase‐1–dependent pathway in rat Kupffer cells

Palash Mandal, Pil‐Hoon Park, Megan R. McMullen, Brian T. Pratt, Laura E. Nagy – 26 March 2010 – Altered expression and activity of immunomodulatory cytokines plays a major role in the pathogenesis of alcoholic liver disease. Chronic ethanol feeding increases the sensitivity of Kupffer cells, the resident hepatic macrophage, to lipopolysaccharide (LPS), leading to increased tumor necrosis factor alpha (TNF‐α) expression. This sensitization is normalized by treatment of primary cultures of Kupffer cells with adiponectin, an anti‐inflammatory adipokine.

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