Henriette E. Meyer zu Schwabedissen, Kerstin Böttcher, Amarjit Chaudhry, Heyo K. Kroemer, Erin G. Schuetz, Richard B. Kim – 29 October 2010 – Organic anion transporting polypeptide 1B1 (OATP1B1) is a liver‐enriched transporter involved in the hepatocellular uptake of many endogenous molecules and several structurally divergent drugs in clinical use. Although OATP1B1 coding region polymorphisms are known to make an impact on substrate drug disposition in humans, little is known regarding the mechanisms underlying the transcriptional regulation of this transporter.

Son T. Pham, Rowena A. Bull, James M. Bennett, William D. Rawlinson, Gregory J. Dore, Andrew R. Lloyd, Peter A. White – 29 October 2010 – Recent data indicate that multiple hepatitis C virus (HCV) infections (mixed infection, superinfection, and reinfection) are common among injection drug users (IDUs). In this study, we identified and characterized multiple HCV infection episodes among HCV‐seronegative IDU prison inmates (n = 488) enrolled in the Hepatitis C Incidence and Transmission Study cohort.

Jin‐Ping Lai, Abdul M. Oseini, Catherine D. Moser, Chunrong Yu, Sherine F. Elsawa, Chunling Hu, Ikuo Nakamura, Tao Han, Ileana Aderca, Hajime Isomoto, Megan M. Garrity‐Park, Abdirashid M. Shire, Jia Li, Schuyler O. Sanderson, Alex A. Adjei, Martin E. Fernandez‐Zapico, Lewis R. Roberts – 29 October 2010 – Heparan sulfate proteoglycans (HSPGs) act as coreceptors or storage sites for growth factors and cytokines such as fibroblast growth factor and Wnts. Glypican 3 (GPC3) is the most highly expressed HSPG in hepatocellular carcinoma (HCC).

Lucia Pacifico, Caterina Anania, Francesco Martino, Vito Cantisani, Roberto Pascone, Andrea Marcantonio, Claudio Chiesa – 29 October 2010 – Nonalcoholic fatty liver disease (NAFLD) has been consistently found to be associated with features of the metabolic syndrome (MS), a condition carrying a high risk of cardiovascular events. The present study aimed to determine whether, in children and adolescents, NAFLD is atherogenic beyond its association with MS and its components.

Nirupa Sachithanandan, Barbara C. Fam, Stacey Fynch, Nicolas Dzamko, Matthew J. Watt, Sam Wormald, Jane Honeyman, Sandra Galic, Joseph Proietto, Sofianos Andrikopoulos, Andrea L. Hevener, Thomas W.H. Kay, Gregory R. Steinberg – 29 October 2010 – Obesity is associated with chronic inflammation and contributes to the development of insulin resistance and nonalcoholic fatty liver disease. The suppressor of cytokine signaling‐3 (SOCS3) protein is increased in inflammation and is thought to contribute to the pathogenesis of insulin resistance by inhibiting insulin and leptin signaling.

Dipali Sharma, Jason Wang, Ping P. Fu, Shvetank Sharma, Arumugam Nagalingam, Jamie Mells, Jeffrey Handy, Andrew J. Page, Cynthia Cohen, Frank A. Anania, Neeraj K. Saxena – 29 October 2010 – Obesity is rapidly becoming a pandemic and is associated with increased carcinogenesis. Obese populations have higher circulating levels of leptin in contrast to low concentrations of adiponectin. Hence, it is important to evaluate the dynamic role between adiponectin and leptin in obesity‐related carcinogenesis.

Jeremy Durack, Nathan Bass, David Teitel, Robert Kerlan, John Roberts – 28 October 2010

Hung‐Tien Kuo, Christine Lau, Marcelo Santos Sampaio, Suphamai Bunnapradist – 28 October 2010 – Our objectives are to examine the incidence of new‐onset diabetes mellitus after transplant (NODAT) and to identify its risk factors in pediatric liver transplant recipients using the Organ Procurement and Transplant Network/United Network for Organ Sharing database. Between July 2004 and December 2008, a total of 1214 children (2‐20 years old) received their first liver transplant alone, and had at least 1 follow‐up report of posttransplant diabetic status.

Celina M. Yong, Madan Sharma, Victor Ochoa, Freddy Abnousi, John Roberts, Nathan M. Bass, Claus U. Niemann, Stephen Shiboski, Megha Prasad, Mehdi Tavakol, Thomas A. Ports, Gabriel Gregoratos, Yerem Yeghiazarians, Andrew J. Boyle – 28 October 2010 – The optimal preoperative cardiac evaluation strategy for patients with end‐stage liver disease (ESLD) undergoing liver transplantation remains unknown. Patients are frequently referred for cardiac catheterization, but the effects of coronary artery disease (CAD) on posttransplant mortality are also unknown.

Andrew J. Portal, Mark J. W. McPhail, Matthew Bruce, Iona Coltart, Andrew Slack, Roy Sherwood, Nigel D. Heaton, Debbie Shawcross, Julia A. Wendon, Michael A. Heneghan – 28 October 2010 – Postoperative acute kidney injury (AKI) increases morbidity and mortality after liver transplantation (LT). Novel methods of assessing AKI including cystatin C (CyC) and neutrophil gelatinase–associated lipocalin (NGAL) have been identified as potential markers of AKI.