Drug therapy: Sorafenib
Richard S. Finn – 22 April 2010
Fatty liver: Think globally
James E. Everhart, Kiran M. Bambha – 22 April 2010
Down‐regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma
Li Fu, Sui‐Sui Dong, Yi‐Wu Xie, Lai‐Shan Tai, Leilei Chen, Kar Lok Kong, Kwan Man, Dan Xie, Yan Li, Yingduan Cheng, Qian Tao, Xin‐Yuan Guan – 22 April 2010 – Loss of 16q is one of the most frequent alterations in many malignancies including hepatocellular carcinomas (HCC), suggesting the existence of a tumor suppressor gene (TSG) within the frequently deleted region. In this report we describe the identification and characterization of one candidate TSG, tyrosine aminotransferase gene (TAT), at 16q22.1.
Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine‐45 mutant β‐catenin
Kari N. Nejak‐Bowen, Michael D. Thompson, Sucha Singh, William C. Bowen, Mohd Jamal Dar, Jaspal Khillan, Chunsun Dai, Satdarshan P.S. Monga – 22 April 2010 – The Wnt/β‐catenin pathway is implicated in the pathogenesis of hepatocellular cancer (HCC). We developed a transgenic mouse (TG) in the FVB strain that overexpresses Ser45‐mutated‐β‐catenin in hepatocytes to study the effects on liver regeneration and cancer. In the two independent TG lines adult mice show elevated β‐catenin at hepatocyte membrane with no increase in the Wnt pathway targets cyclin‐D1 or glutamine synthetase.
Thiazolidinediones as potent inducers of hepatocyte growth factor
Wataru Ito, Shigeharu Ueki, Masahide Takeda, Tomomi Tanigai, Hiroyuki Kayaba, Junichi Chihara – 22 April 2010
MicroRNA‐196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins
Weihong Hou, Qing Tian, Jianyu Zheng, Herbert L. Bonkovsky – 22 April 2010 – Hepatitis C virus (HCV) directly induces oxidative stress and liver injury. Bach1, a basic leucine zipper mammalian transcriptional repressor, negatively regulates heme oxygenase 1 (HMOX1), a key cytoprotective enzyme that has antioxidant and anti‐inflammatory activities. microRNAs (miRNAs) are small noncoding RNAs (≈22 nt) that are important regulators of gene expression. Whether and how miRNAs regulate Bach1 or HCV are largely unknown.
Vanishing bile duct syndrome associated with peripheral T cell lymphoma, not otherwise specified, arising in a posttransplant setting
Ryan M. Gill, Linda D. Ferrell – 22 April 2010
Is oil red‐O staining and digital image analysis the gold standard for quantifying steatosis in the liver?
Adam P. Levene, Hiromi Kudo, Mark R. Thursz, Quentin M. Anstee, Robert D. Goldin – 22 April 2010
Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor‐β
Hanning You, Wei Ding, C. Bart Rountree – 22 April 2010 – Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. CD133, a transmembrane glycoprotein, is an important cell surface marker for both stem cells and cancer stem cells in various tissues including liver. CD133 expression has been recently linked to poor prognosis in HCC patients. CD133+ liver cancer cells are characterized by resistance to chemotherapy, self‐renewal, multilineage potential, increased colony formation, and in vivo cancer initiation at limited dilution.
ATP8B1 and ABCB11 analysis in 62 children with normal gamma‐glutamyl transferase progressive familial intrahepatic cholestasis (PFIC): Phenotypic differences between PFIC1 and PFIC2 and natural history
Anne Davit‐Spraul, Monique Fabre, Sophie Branchereau, Christiane Baussan, Emmanuel Gonzales, Bruno Stieger, Olivier Bernard, Emmanuel Jacquemin – 22 April 2010 – Progressive familial intrahepatic cholestasis (PFIC) types 1 and 2 are characterized by normal serum gamma‐glutamyl transferase (GGT) activity and are due to mutations in ATP8B1 (encoding FIC1) and ABCB11 (encoding bile salt export pump [BSEP]), respectively. Our goal was to evaluate the features that may distinguish PFIC1 from PFIC2 and ease their diagnosis.