Nonalcoholic fatty liver in a developing country is responsible for significant liver disease
Ajay Duseja, Balkrishan Sharma, Amit Kumar, Shweta Kapil, Ashim Das, Radha K. Dhiman, Yogesh K. Chawla – 23 November 2010
Adipose to the rescue: Peripheral fat fuels liver regeneration
Sundararajah Thevananther – 23 November 2010
Liver enzymes and cardiovascular outcomes: A new research agenda
Yusuf Yilmaz, Ramazan Kurt, Cem Kalayci – 23 November 2010
Drug‐induced autoimmune hepatitis caused by anti–tumor necrosis factor α agents
Cumali Efe, Tugrul Purnak, Ersan Ozaslan, Staffan Wahlin – 23 November 2010
Treatment response in patients with autoimmune hepatitis
Christoph Schramm, Christina Weiler‐Normann, Christiane Wiegard, Stefanie Hellweg, Susanne Müller, Ansgar W. Lohse – 23 November 2010
The balancing act of hepatocyte apoptosis
Nicholas A. Shackel – 23 November 2010 – The cell death receptor Fas plays a role in the establishment of fulminant hepatitis, a major cause of drug‐induced liver failure. Fas activation elicits extrinsic apoptotic and hepatoprotective signals; however, the mechanisms by which these signals are integrated during disease are unknown. Tissue inhibitor of metalloproteinases 3 (TIMP3) controls the critical sheddase a disintegrin and metalloproteinase 17 (ADAM17) and may dictate stress signaling.
2010 Hepatology referees (Volumes 51 and 52)
23 November 2010
Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin‐28B genotype
Alexander J. Thompson, Andrew J. Muir, Mark S. Sulkowski, Keyur Patel, Hans L. Tillmann, Paul J. Clark, Susanna Naggie, Jacques Fellay, Dongliang Ge, Jeanette J. McCarthy, David B. Goldstein, John G. McHutchison – 23 November 2010
Teaching New Tricks to an Old Foe: Murinizing Hepatitis C Virus
Gisa Gerold, Charles M. Rice, Alexander Ploss – 23 November 2010 – Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined. Virus cell entry involves human scavenger receptor class B type I (SR‐BI), CD81, claudin‐1 and occludin. Among these, at least CD81 and occludin are utilized in a highly species‐specific fashion, thus contributing to the narrow host range of HCV.
Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma
Sen‐Yung Hsieh, Jung‐Ru He, Chih‐Yun Hsu, Wan‐Ju Chen, Rabindranath Bera, Kuo‐Yang Lin, Tsung‐Chieh Shih, Ming‐Chin Yu, Yu‐Jr Lin, Chee‐Jen Chang, Wen‐Hui Weng, Shiu‐Fen Huang – 19 November 2010 – Intrahepatic metastasis is the primary cause of the high recurrence and poor prognosis of human hepatocellular carcinoma (HCC). However, neither its molecular mechanisms nor markers for its prediction before hepatectomy have been identified. We recently revealed up‐regulation of erythroblastic leukemia viral oncogene homolog 3 (ERBB3) in human HCC.