Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: The Framingham heart study

Elizabeth K. Speliotes, Joseph M. Massaro, Udo Hoffmann, Ramachandran S. Vasan, James B. Meigs, Dushyant V. Sahani, Joel N. Hirschhorn, Christopher J. O'Donnell, Caroline S. Fox – 23 May 2010 – Obesity is not uniformly associated with the development of metabolic sequelae. Specific patterns of body fat distribution, in particular fatty liver, may preferentially predispose at‐risk individuals to disease. In this study, we characterize the metabolic correlates of fat in the liver in a large community‐based sample with and without respect to visceral fat.

A flippase‐independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

Patricia M. Verhulst, Lieke M. van der Velden, Viola Oorschot, Ernst E. van Faassen, Judith Klumperman, Roderick H. J. Houwen, Thomas G. Pomorski, Joost C. M. Holthuis, Leo W. J. Klomp – 23 May 2010 – Mutations in ATP8B1 cause familial intrahepatic cholestasis type 1, a spectrum of disorders characterized by intrahepatic cholestasis, reduced growth, deafness, and diarrhea.

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

Mustafa S. Ascha, Ibrahim A. Hanouneh, Rocio Lopez, Tarek Abu‐Rajab Tamimi, Ariel F. Feldstein, Nizar N. Zein – 23 May 2010 – Nonalcoholic steatohepatitis (NASH) is a well‐recognized cause of cirrhosis and has been increasingly associated with the development of hepatocellular carcinoma (HCC).

Preapoptotic cell stress response of primary hepatocytes

Damijan Nipič, Aleš Pirc, Blaž Banič, Dušan Šuput, Irina Milisav – 23 May 2010 – Primary hepatocytes are an important in vitro model for studying metabolism in man. Caspase‐9 and Bcl‐2‐associated X protein (Bax) are regulators of the apoptotic pathway. Here we report on the translocation of procaspase‐9 and Bax from cytoplasm to nuclei as well as on dispersion of mitochondria; these processes occur after isolation of primary hepatocytes.

Colon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ‐specific antitumor immunity through interleukin‐1‐induced mannose receptor in mice

Beatriz Arteta, Nerea Lasuen, Aritz Lopategi, Baldur Sveinbjörnsson, Bård Smedsrød, Fernando Vidal‐Vanaclocha – 23 May 2010 – Mannose receptor (ManR)‐mediated liver sinusoidal endothelial cell (LSEC) endocytosis plays a role in antigen presentation and innate immunity, but its role in hepatic metastasis is unknown. We studied ManR‐mediated endocytosis during C26 colorectal cancer cell interaction with LSECs and its implications in metastasis. Uptake of labeled ManR ligands (mannan and ovalbumin) and immunohistochemistry were used to study ManR endocytosis and expression.

Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis

Brendan M. McGuire, Igor A. Zupanets, Mark E. Lowe, Xunjun Xiao, Vasyliy A. Syplyviy, Jon Monteleone, Sharron Gargosky, Klara Dickinson, Antonia Martinez, Masoud Mokhtarani, Bruce F. Scharschmidt – 23 May 2010 – Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium phenylbutyrate (NaPBA), mediates waste nitrogen excretion via combination of PBA‐derived phenylacetic acid with glutamine to form phenylactylglutamine (PAGN) that is excreted in urine.

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