Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis
Brendan M. McGuire, Igor A. Zupanets, Mark E. Lowe, Xunjun Xiao, Vasyliy A. Syplyviy, Jon Monteleone, Sharron Gargosky, Klara Dickinson, Antonia Martinez, Masoud Mokhtarani, Bruce F. Scharschmidt – 23 May 2010 – Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium phenylbutyrate (NaPBA), mediates waste nitrogen excretion via combination of PBA‐derived phenylacetic acid with glutamine to form phenylactylglutamine (PAGN) that is excreted in urine.