Potential of curcumin as a multifunctional agent to combat Wilson disease
Hong‐Fang Ji, Liang Shen – 23 May 2010
Treatment with the leukotriene inhibitor montelukast for 10 days attenuates portal hypertension in rat liver cirrhosis
Christian J. Steib, Manfred Bilzer, Mark op den Winkel, Susanne Pfeiler, Anna C. Hartmann, Martin Hennenberg, Burkhard Göke, Alexander L. Gerbes – 23 May 2010 – The mechanisms underlying intrahepatic vasoconstriction are not fully elucidated. Here we investigated the Kupffer cell (KC)‐dependent increase in portal pressure by way of actions of vasoconstrictive cysteinyl leukotrienes (Cys‐LTs). Liver cirrhosis was induced in rats by bile duct ligation (BDL for 4 weeks; controls: sham‐operation) and thioacetamide application (18 weeks).
Causality assessment in drug‐induced liver injury using a structured expert opinion process: Comparison to the Roussel‐Uclaf causality assessment method
Don C. Rockey, Leonard B. Seeff, James Rochon, James Freston, Naga Chalasani, Maurizio Bonacini, Robert J. Fontana, Paul H. Hayashi, for the US Drug‐Induced Liver Injury Network – 23 May 2010 – Drug‐induced liver injury (DILI) is largely a diagnosis of exclusion and is therefore challenging. The US Drug‐Induced Liver Injury Network (DILIN) prospective study used two methods to assess DILI causality: a structured expert opinion process and the Roussel‐Uclaf Causality Assessment Method (RUCAM).
The impact of maternal high‐fat feeding on liver and abdominal fat accumulation in adult offspring under a long‐term high‐fat diet
Adriana L. Burgueño, Julieta Carabelli, Silvia Sookoian, Carlos J. Pirola – 23 May 2010
Two hypotheses for decreasing hepatic encephalopathy risk after transjugular intrahepatic portosystemic shunt
Ming Bai, Guohong Han, Xingshun Qi, Zhanxin Yin, Daiming Fan – 23 May 2010
Metabolic syndrome and obesity as additional factors that determine clinical response in chronic hepatitis C
Tugrul Purnak, Cumali Efe, Yavuz Beyazit, Ersan Ozaslan – 23 May 2010
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Peter V. E. van den Berghe, Roderick H. J. Houwen, Leo W. J. Klomp – 23 May 2010
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
Wing‐Kin Syn, Ye Htun Oo, Thiago A. Pereira, Gamze F. Karaca, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve S. Choi, Cynthia D. Guy, Caitlin M. Fearing, Vanessa Teaberry, Fausto E.L. Pereira, David H. Adams, Anna Mae Diehl – 23 May 2010 – Liver inflammation is greater in nonalcoholic steatohepatitis (NASH) than steatosis, suggesting that immune responses contribute to nonalcoholic fatty liver disease (NAFLD) progression. Livers normally contain many natural killer T (NKT) cells that produce factors that modulate inflammatory and fibrogenic responses.
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury
Barbara A. Wetmore, Dominique J. Brees, Reetu Singh, Paul B. Watkins, Melvin E. Andersen, James Loy, Russell S. Thomas – 23 May 2010 – Serum aminotransferases have been the clinical standard for evaluating liver injury for the past 50‐60 years. These tissue enzymes lack specificity, also tracking injury to other tissues. New technologies assessing tissue‐specific messenger RNA (mRNA) release into blood should provide greater specificity and permit indirect assessment of gene expression status of injured tissue.
Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis
Stuart F. W. Kendrick, Graeme O'Boyle, Jelena Mann, Mujdat Zeybel, Jeremy Palmer, David E. J. Jones, Chris P. Day – 23 May 2010 – Acute alcoholic hepatitis is characterized by disproportionate macrophage inflammatory cytokine responses to bacterial lipopolysaccharide. Lack of knowledge of the underlying mechanism has limited progress toward effective therapy. We postulated a novel mechanism by which ethanol increases histone acetylation, increasing proinflammatory gene transcription and cytokine synthesis.