Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Jörg Schrader, Timothy T. Gordon‐Walker, Rebecca L. Aucott, Mariëlle van Deemter, Alexander Quaas, Shaun Walsh, Daniel Benten, Stuart J. Forbes, Rebecca G. Wells, John P. Iredale – 14 December 2010 – There is increasing evidence that the physical environment is a critical mediator of tumor behavior. Hepatocellular carcinoma (HCC) develops within an altered biomechanical environment, and increasing matrix stiffness is a strong predictor of HCC development.

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration

Mariëlle Verweij, Tessa M. van Ginhoven, James R. Mitchell, Wim Sluiter, Sandra van den Engel, Henk P. Roest, Elham Torabi, Jan N. M. IJzermans, Jan H. J. Hoeijmakers, Ron W. F. de Bruin – 14 December 2010 – We show that brief periods of fasting induce functional changes similar to those induced by long‐term dietary restriction in mice, and these changes include protection from ischemia/reperfusion (I/R) injury. In this study, we investigated the mechanisms of protection induced by fasting, and we determined the effect on liver regeneration after partial hepatectomy.

Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans

So‐Mi Yoon, Domniki Gerasimidou, Reiichiro Kuwahara, Prodromos Hytiroglou, Jeong Eun Yoo, Young Nyun Park, Neil D. Theise – 14 December 2010 – Epithelial cell adhesion molecule (EpCAM) is a surface marker on human hepatic stem/progenitor cells that is reported as absent on mature hepatocytes.

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