Boris Görg, Natalia Qvartskhava, Hans‐Jürgen Bidmon, Nicola Palomero‐Gallagher, Gerald Kircheis, Karl Zilles, Dieter Häussinger – 23 June 2010 – Cell culture studies and animal models point to an important role of oxidative/nitrosative stress in the pathogenesis of cerebral ammonia toxicity. However, it is unknown whether oxidative/nitrosative stress in the brain is also characteristic of hepatic encephalopathy (HE) in humans.

Atsushi Matsuda, Atsushi Kuno, Toru Kawamoto, Hideki Matsuzaki, Tatsuro Irimura, Yuzuru Ikehara, Yoh Zen, Yasuni Nakanuma, Masakazu Yamamoto, Nobuhiro Ohkohchi, Junichi Shoda, Jun Hirabayashi, Hisashi Narimatsu – 23 June 2010 – Cholangiocarcinoma (CC) is an aggressive malignant tumor for which useful markers are not presently available for early and precise diagnosis. The aim of this study was therefore to identify a high‐performance diagnostic marker with a special focus on glyco‐alteration of glycoproteins.

Marina G. Silveira, Elizabeth M. Brunt, Jenny Heathcote, Gregory J. Gores, Keith D. Lindor, Marlyn J. Mayo – 23 June 2010

Abby B. Siegel, Sonja K. Olsen, Arthur Magun, Robert S. Brown – 23 June 2010 – The approval of sorafenib as the first effective drug for the treatment of hepatocellular carcinoma (HCC) represents a milestone in the treatment of this disease. A better understanding of HCC pathogenesis has led to the development of several novel targeted treatments. HCC is treated in a uniquely multidisciplinary way requiring surgeons, hepatologists, interventional radiologists, and oncologists.

Matthew W. Lawless – 23 June 2010

Jinfeng Huang, Yue Wang, Yingjun Guo, Shuhan Sun – 23 June 2010 – The hepatitis B virus (HBV) X protein has been implicated as a potential trigger of the epigenetic modifications of some genes during hepatocarcinogenesis, but the underlying mechanisms remain unknown. MicroRNAs (miRNAs), which are noncoding RNAs that regulate gene expression, are involved in diverse biological functions and in carcinogenesis.

Philipp A. Lang, Mike Recher, Nadine Honke, Stefanie Scheu, Stephanie Borkens, Nicole Gailus, Caroline Krings, Andreas Meryk, Andreas Kulawik, Luisa Cervantes‐Barragan, Nico Van Rooijen, Ulrich Kalinke, Burkhard Ludewig, Hans Hengartner, Nicola Harris, Dieter Häussinger, Pamela S. Ohashi, Rolf M. Zinkernagel, Karl S. Lang – 23 June 2010 – The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process.

Marta Varela‐Rey, Nuria Martínez‐López, David Fernández‐Ramos, Nieves Embade, Diego F. Calvisi, Aswhin Woodhoo, Juan Rodríguez, Mario F. Fraga, Josep Julve, Elisabeth Rodríguez‐Millán, Itziar Frades, Luís Torres, Zigmund Luka, Conrad Wagner, Manel Esteller, Shelly C. Lu, M. Luz Martínez‐Chantar, José M. Mato – 23 June 2010 – Deletion of glycine N‐methyltransferase (GNMT), the main gene involved in liver S‐adenosylmethionine (SAM) catabolism, leads to the hepatic accumulation of this molecule and the development of fatty liver and fibrosis in mice.

Ayse L. Mindikoglu, Arie Regev, Stephen L. Seliger, Laurence S. Magder – 18 June 2010 – Previous studies of men and women on the liver transplantation (LT) waiting list, without taking transplantation rates into account, have suggested a higher risk of mortality for women on the waiting list. The objective of this study was to compare men and women with respect to dying within 3 years of registration on the LT waiting list and to take into account both the immediate mortality risks and the transplantation rates.

Franco Bonaguidi, Claudio Michelassi, Franco Filipponi, Daniele Rovai – 18 June 2010 – We tested the hypothesis that religiosity (ie, seeking God's help, having faith in God, trusting in God, and trying to perceive God's will in the disease) is associated with improved survival in patients with end‐stage liver disease who have undergone orthotopic liver transplantation. We studied a group of 179 candidates for liver transplantation who responded to a questionnaire on religiosity during the pretransplant psychological evaluation and underwent transplantation between 2004 and 2007.