Aquaporin‐1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis

Robert C. Huebert, Meher M. Vasdev, Uday Shergill, Amitava Das, Bing Q. Huang, Michael R. Charlton, Nicholas F. LaRusso, Vijay H. Shah – 23 June 2010 – Increasing evidence suggests that hepatic fibrosis and pathological angiogenesis are interdependent processes that occur in parallel. Endothelial cell invasion is requisite for angiogenesis, and thus studies of the mechanisms governing liver endothelial cell (LEC) invasion during cirrhosis are of great importance.

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

Ana Blas‐García, Nadezda Apostolova, Daniel Ballesteros, Daniel Monleón, Jose M. Morales, Milagros Rocha, Victor M. Victor, Juan V. Esplugues – 23 June 2010 – Efavirenz (EFV) is a non‐nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been associated with hepatotoxic effects and alterations in lipid and body fat composition.

Detection of the imbalance of procoagulant versus anticoagulant factors in cirrhosis by a simple laboratory method

Armando Tripodi, Massimo Primignani, Laura Lemma, Veena Chantarangkul, Alessandra Dell'Era, Francesca Iannuzzi, Alessio Aghemo, Pier Mannuccio Mannucci – 23 June 2010 – Patients with cirrhosis possess an imbalance in procoagulant versus anticoagulant activity due to increased factor VIII and decreased protein C. This imbalance can be detected by thrombin‐generation assays performed in the presence/absence of thrombomodulin (predicate assay) that are not readily available in clinical laboratories.

Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug‐induced liver injury

M. Isabel Lucena, Elena García‐Martín, Raúl J. Andrade, Carmen Martínez, Camilla Stephens, Jhon D. Ruiz, Eugenia Ulzurrun, M. Carmen Fernandez, Manuel Romero‐Gomez, Augustin Castiella, Ramon Planas, José Antonio Durán, Ana Melcón De Dios, Carlos Guarner, German Soriano, Yolanda Borraz, José A. G. Agundez – 23 June 2010 – Drug‐induced liver injury (DILI) susceptibility has a potential genetic basis.

Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis

Hong‐Min Ni, Catherine J. Baty, Na Li, Wen‐Xing Ding, Wentao Gao, Min Li, Xiaoyun Chen, Jianjie Ma, George K. Michalopoulos, Xiao‐Ming Yin – 23 June 2010 – BH3‐interacting domain death agonist (Bid), a BH3‐only B cell lymphoma 2 family molecule, is generally known for its importance in activating the mitochondrial apoptosis pathway after death receptor engagement, particularly in hepatocytes. However, Bid also promotes hepatocyte proliferation during liver regeneration and carcinogenesis.

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