Ana Blas‐García, Nadezda Apostolova, Daniel Ballesteros, Daniel Monleón, Jose M. Morales, Milagros Rocha, Victor M. Victor, Juan V. Esplugues – 23 June 2010 – Efavirenz (EFV) is a non‐nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been associated with hepatotoxic effects and alterations in lipid and body fat composition.
Armando Tripodi, Massimo Primignani, Laura Lemma, Veena Chantarangkul, Alessandra Dell'Era, Francesca Iannuzzi, Alessio Aghemo, Pier Mannuccio Mannucci – 23 June 2010 – Patients with cirrhosis possess an imbalance in procoagulant versus anticoagulant activity due to increased factor VIII and decreased protein C. This imbalance can be detected by thrombin‐generation assays performed in the presence/absence of thrombomodulin (predicate assay) that are not readily available in clinical laboratories.
M. Isabel Lucena, Elena García‐Martín, Raúl J. Andrade, Carmen Martínez, Camilla Stephens, Jhon D. Ruiz, Eugenia Ulzurrun, M. Carmen Fernandez, Manuel Romero‐Gomez, Augustin Castiella, Ramon Planas, José Antonio Durán, Ana Melcón De Dios, Carlos Guarner, German Soriano, Yolanda Borraz, José A. G. Agundez – 23 June 2010 – Drug‐induced liver injury (DILI) susceptibility has a potential genetic basis.
Hong‐Min Ni, Catherine J. Baty, Na Li, Wen‐Xing Ding, Wentao Gao, Min Li, Xiaoyun Chen, Jianjie Ma, George K. Michalopoulos, Xiao‐Ming Yin – 23 June 2010 – BH3‐interacting domain death agonist (Bid), a BH3‐only B cell lymphoma 2 family molecule, is generally known for its importance in activating the mitochondrial apoptosis pathway after death receptor engagement, particularly in hepatocytes. However, Bid also promotes hepatocyte proliferation during liver regeneration and carcinogenesis.
Tobias J. Weismüller, Michael P. Manns, Christian P. Strassburg – 23 June 2010
Yucel Ustundag, Omer Topalak – 23 June 2010
Marc Lutgehetmann, Tassilo Volz, Anne Köpke, Tim Broja, Eike Tigges, Ansgar W. Lohse, Eberhard Fuchs, John M. Murray, Joerg Petersen, Maura Dandri – 23 June 2010 – Chronic hepatitis B virus (HBV) infection is maintained by the presence of covalently closed circular DNA (cccDNA), the template of viral transcription and replication. In quiescent hepatocytes, cccDNA is a stable molecule that can persist throughout the hepatocyte lifespan.
Cyrill Géraud, Kai Schledzewski, Alexandra Demory, Diana Klein, Miriam Kaus, Francis Peyre, Carsten Sticht, Konstantin Evdokimov, Shun Lu, Astrid Schmieder, Sergij Goerdt – 23 June 2010 – Liver sinusoidal endothelium (LSEC) is a prime example of organ‐specific microvascular differentiation and functions. Disease‐associated capillarization of LSEC in vivo and dedifferentiation of LSEC in vitro indicate the importance of the hepatic microenvironment.
Akif Altinbas, Fuat Ekiz, Osman Yuksel – 23 June 2010
Gin‐Ho Lo, Wen‐Chi Chen, Huay‐Min Wang, Ching‐Chang Lee – 23 June 2010 – Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high‐risk esophageal varices but without a bleeding history were considered for enrolment. Eligible patients were randomized to receive band ligation plus nadolol (Combined group, 70 patients) or nadolol alone (Nadolol group, 70 patients). In the Combined group multiligators were applied.