Andrew X. Zhu, Aram F. Hezel – 11 January 2011 – Biliary tract cancers (BTCs), which encompass intra‐ and extrahepatic cholangiocarcinomas as well as gallbladder carcinomas, are a genetically diverse collection of cancers. Most patients with BTC will present with unresectable or metastatic disease. Although the standard systemic chemotherapy approaches are emerging, the prognosis remains poor. Development of molecularly targeted therapies in advanced BTC remains challenging.

Philip Meuleman, Jens Bukh, Lieven Verhoye, Ali Farhoudi, Thomas Vanwolleghem, Richard Y. Wang, Isabelle Desombere, Harvey Alter, Robert H. Purcell, Geert Leroux‐Roels – 11 January 2011 – Control of hepatitis C virus (HCV) infection remains a huge challenge of global medical importance. Using a variety of in vitro approaches, neutralizing antibodies (nAbs) have been identified in patients with acute and chronic hepatitis C. The exact role these nAbs play in the resolution of acute HCV infection still remains elusive.

Catherine Schuster, Mathieu Lefèvre, Thomas F. Baumert – 11 January 2011

Tiago C. Alves, Douglas E. Befroy, Richard G. Kibbey, Mario Kahn, Roberto Codella, Rui A. Carvalho, Kitt Falk Petersen, Gerald I. Shulman – 11 January 2011 – Pyruvate dehydrogenase plays a critical role in the regulation of hepatic glucose and fatty acid oxidation; however, surprisingly little is known about its regulation in vivo. In this study we examined the individual effects of insulin and substrate availability on the regulation of pyruvate dehydrogenase flux (VPDH) to tricarboxylic acid flux (VTCA) in livers of awake rats with lipid‐induced hepatic insulin resistance.

Jeff Fidler, David Hough – 11 January 2011

Tetsuji Fujita – 11 January 2011

Elsa Solà, Sabela Lens, Mónica Guevara, Pere Ginès – 11 January 2011

Adrian M. Di Bisceglie, Anne M. Stoddard, Jules L. Dienstag, Mitchell L. Shiffman, Leonard B. Seeff, Herbert L. Bonkovsky, Chihiro Morishima, Elizabeth C. Wright, Kristin K. Snow, William M. Lee, Robert J. Fontana, Timothy R. Morgan, Marc G. Ghany, for the HALT‐C Trial Group – 11 January 2011 – Chronic hepatitis C virus infection can cause chronic liver disease, cirrhosis and liver cancer.

Melania Manco, Anna Alisi, Antonella Mosca, Valerio Nobili – 11 January 2011

John M. Vierling – 11 January 2011