Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: An association with C2 monitoring and recipient age

Angela S. W. Tjon, Jerome Sint Nicolaas, Jaap Kwekkeboom, Robert A. de Man, Geert Kazemier, Hugo W. Tilanus, Bettina E. Hansen, Luc J. W. van der Laan, Thanyalak Tha‐In, Herold J. Metselaar – 25 June 2010 – The goal of this study was to determine the risk factors for de novo cancer after liver transplantation (LTx). Retrospective analyses were performed in 385 LTx patients who underwent transplantation between 1986 and 2007. In total, 50 (13.0%) recipients developed de novo malignancy.

Safety of small‐for‐size grafts in adult‐to‐adult living donor liver transplantation using the right lobe

Ju Ik Moon, Choon Hyuck David Kwon, Jae‐Won Joh, Gum O. Jung, Gyu‐Seong Choi, Jae Berm Park, Jong Man Kim, Milljae Shin, Sung‐Joo Kim, Suk‐Koo Lee – 25 June 2010 – The problem of graft size is one of the critical factors limiting the expansion of adult‐to‐adult living donor liver transplantation (LDLT). We compared the outcome of LDLT recipients who received grafts with a graft‐to‐recipient weight ratio (GRWR) < 0.8% or a GRWR ≥ 0.8%, and we analyzed the risk factors affecting graft survival after small‐for‐size grafts (SFSGs) were used.

Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T‐lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: Evidence for a gene–gene interaction

Brian D. Juran, Elizabeth J. Atkinson, Joseph J. Larson, Erik M. Schlicht, Xiangdong Liu, E. Jenny Heathcote, Gideon M. Hirschfield, Katherine A. Siminovitch, Konstantinos N. Lazaridis – 23 June 2010 – Common genetic variants significantly influence complex diseases such as primary biliary cirrhosis (PBC). We recently reported an association between PBC and a single nucleotide polymorphism (rs231725) of the immunoreceptor gene cytotoxic T‐lymphocyte antigen 4 (CTLA4).

Theophylline improves steroid sensitivity in acute alcoholic hepatitis

Stuart F. W. Kendrick, Elsbeth Henderson, Jeremy Palmer, David E. J. Jones, Chris P. Day – 23 June 2010 – Corticosteroid therapy has shown some benefit in severe acute alcoholic hepatitis (AAH); however, this is limited by uncertainty in patient selection and variable clinical response. Theophylline has been shown to ameliorate impaired steroid sensitivity in chronic obstructive pulmonary disease by facilitating corticosteroid‐induced silencing of proinflammatory genes.

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