Florie Borel, Ruiqi Han, Allerdien Visser, Harald Petry, Sander J.H. van Deventer, Peter L.M. Jansen, Pavlina Konstantinova, with collaboration of the Réseau Centre de Ressources Biologiques Foie (French Liver Biobanks Network), France – 19 September 2011 – Adenosine triphosphate (ATP)‐binding cassette (ABC) transporters are drug efflux pumps responsible for the multidrug resistance phenotype causing hepatocellular carcinoma (HCC) treatment failure.

Waqar R. R. Farid, Qiuwei Pan, Adriaan J. P. van der Meer, Petra E. de Ruiter, Vedashree Ramakrishnaiah, Jeroen de Jonge, Jaap Kwekkeboom, Harry L. A. Janssen, Herold J. Metselaar, Hugo W. Tilanus, Geert Kazemier, Luc J.W. van der Laan – 19 September 2011 – Recent animal and human studies have highlighted the potential of hepatocyte‐derived microRNAs (HDmiRs) in serum as early, stable, sensitive, and specific biomarkers of liver injury. Their usefulness in human liver transplantation, however, has not been addressed.

Meng Y. Wang, Darryn R. Potosky, Sandeep Khurana – 19 September 2011

Alice Marmugi, Simon Ducheix, Frédéric Lasserre, Arnaud Polizzi, Alain Paris, Nathalie Priymenko, Justine Bertrand‐Michel, Thierry Pineau, Hervé Guillou, Pascal G.P. Martin, Laïla Mselli‐Lakhal – 19 September 2011 – Changes in lifestyle are suspected to have strongly influenced the current obesity epidemic.

Romain Coriat, Olivier Mir, François Goldwasser, Stanislas Pol, Stanislas Chaussade – 19 September 2011

Yoichi Ishizaki, Seiji Kawasaki, Hiroyuki Sugo, Jiro Yoshimoto, Noriko Fujiwara, Hiroshi Imamura – 19 September 2011 – Recently, the successful application of portal inflow modulation has led to renewed interest in the use of left lobe grafts in adult‐to‐adult living donor liver transplantation (LDLT). However, data on the hepatic hemodynamics supporting portal inflow modulation are limited, and the optimal portal circulation for a liver graft is still unclear. We analyzed 42 consecutive adult‐to‐adult left lobe LDLT cases without splenectomy or a portocaval shunt.

Satoshi Goshima, Masayuki Kanematsu, Tatsunori Kobayashi, Takahiro Furukawa, Xuejun Zhang, Hiroshi Fujita, Haruo Watanabe, Hiroshi Kondo, Noriyuki Moriyama, Kyongtae T. Bae – 19 September 2011

Simon Hohenester, Lucas Maillette de Buy Wenniger, Coen C. Paulusma, Sandra J. van Vliet, Douglas M. Jefferson, Ronald P. Oude Elferink, Ulrich Beuers – 19 September 2011 – Human cholangiocytes are continuously exposed to millimolar levels of hydrophobic bile salt monomers. We recently hypothesized that an apical biliary HCO umbrella might prevent the protonation of biliary glycine‐conjugated bile salts and uncontrolled cell entry of the corresponding bile acids, and that defects in this biliary HCO umbrella might predispose to chronic cholangiopathies.

David Fuks, Safi Dokmak, Valérie Paradis, Momar Diouf, François Durand, Jacques Belghiti – 19 September 2011 – Liver resection (LR) for hepatocellular carcinoma (HCC) as the first‐line treatment in transplantable patients followed by “salvage transplantation” (ST) in case of recurrence is an attractive concept. The aim was to identify patients who gain benefit from this approach in an intention‐to‐treat study.

Hong‐Min Ni, Abigail Bockus, Nikki Boggess, Hartmut Jaeschke, Wen‐Xing Ding – 19 September 2011 – Autophagy can selectively remove damaged organelles, including mitochondria, and, in turn, protect against mitochondria‐damage–induced cell death. Acetaminophen (APAP) overdose can cause liver injury in animals and humans by inducing mitochondria damage and subsequent necrosis in hepatocytes. Although many detrimental mechanisms have been reported to be responsible for APAP‐induced hepatotoxicity, it is not known whether APAP can modulate autophagy to regulate hepatotoxicity in hepatocytes.