Increased RNA‐induced silencing complex (RISC) activity contributes to hepatocellular carcinoma
Byoung Kwon Yoo, Prasanna K. Santhekadur, Rachel Gredler, Dong Chen, Luni Emdad, Sujit Bhutia, Lewis Pannell, Paul B. Fisher, Devanand Sarkar – 10 February 2011 – There is virtually no effective treatment for advanced hepatocellular carcinoma (HCC) and novel targets need to be identified to develop effective treatment. We recently documented that the oncogene Astrocyte elevated gene‐1 (AEG‐1) plays a seminal role in hepatocarcinogenesis.