Host apolipoprotein b messenger RNA‐editing enzyme catalytic polypeptide‐like 3G is an innate defensive factor and drug target against hepatitis C virus
Zong‐Gen Peng, Zhi‐Yun Zhao, Yan‐Ping Li, Yu‐Ping Wang, Lan‐Hu Hao, Bo Fan, Yu‐Huan Li, Yue‐Ming Wang, Yong‐Qiang Shan, Yan‐Xing Han, Yan‐Ping Zhu, Jian‐Rui Li, Xue‐Fu You, Zhuo‐Rong Li, Jian‐Dong Jiang – 10 January 2011 – Host cellular factor apolipoprotein B messenger RNA (mRNA)‐editing enzyme catalytic polypeptide‐like 3G (hA3G) is a cytidine deaminase that inhibits a group of viruses including human immunodeficiency virus‐1 (HIV‐1). In the continuation of our research on hA3G, we found that hA3G stabilizing compounds significantly inhibited hepatitis C virus (HCV) replication.