James Neuberger, Sue Madden, David Collett – 16 July 2010 – The assessment of outcomes after transplantation is important for several reasons: it provides patients with data so that they can make informed decisions about the benefits of transplantation and the success of the transplant unit; it informs commissioners that resources are allocated properly; and it provides clinicians reassurance that results are acceptable or, if they are not, provides early warning so that problems can be identified, corrections can be instituted early, and all interested parties can be reassured that scarce

Sung Hwan Ki, Oygi Park, Mingquan Zheng, Oriol Morales‐Ibanez, Jay K. Kolls, Ramon Bataller, Bin Gao – 16 July 2010 – Interleukin‐22 (IL‐22), a recently identified member of the IL‐10 family of cytokines that is produced by Th17 and natural killer cells, plays an important role in controlling bacterial infection, homeostasis, and tissue repair. Here, we tested the effect of IL‐22 on alcohol‐induced liver injury in a murine model of chronic‐binge ethanol feeding.

Sumeet K. Asrani, Michael D. Leise, Colin P. West, M. Hassan Murad, Rachel A. Pedersen, Patricia J. Erwin, Jianmin Tian, Russell H. Wiesner, W. Ray Kim – 16 July 2010 – Sirolimus is used in patients with renal insufficiency after liver transplantation (LT) and especially in those with calcineurin inhibitor (CNI)–associated nephrotoxicity.

Gian Luigi Adani, Anna Rossetto, Vittorio Bresadola, Umberto Baccarani – 16 July 2010

Hayato Hikita, Tetsuo Takehara, Satoshi Shimizu, Takahiro Kodama, Minoru Shigekawa, Kyoko Iwase, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi – 16 July 2010 – Tumor cells are characterized by uncontrolled proliferation, often driven by activation of oncogenes, and apoptosis resistance.

Claire Francoz, Dominique Prié, Wael AbdelRazek, Richard Moreau, Ameet Mandot, Jacques Belghiti, Dominique Valla, François Durand – 16 July 2010 – Renal function has a significant impact on early mortality in patients with cirrhosis. However, creatinine and creatinine‐based equations are inaccurate markers of renal function in cirrhosis. The aim of this study was to reassess correlations between creatinine‐based equations and measured glomerular filtration rate (GFR) and to investigate the impact of inaccuracies on the Model for End‐Stage Liver Disease (MELD) score.

Willscott E. Naugler, Amnon Sonnenberg – 16 July 2010 – The aim of the present study is to compare the survival rates and cost‐effectiveness of different treatment strategies for small (<2 cm) hepatocellular carcinoma (HCC). Markov chains are developed to model different management strategies for patients with compensated cirrhosis and small HCC. Probabilities of progression and survival and the likelihood of orthotopic liver transplantation are taken from the literature and incorporated into the models. As a starting population, 1000 patients are followed over a period of 10 years.

Emmanuel Weiss, Souhayl Dahmani, Frederic Bert, Sylvie Janny, Daniel Sommacale, Federica Dondero, Claire Francoz, Jacques Belghiti, Jean Mantz, Catherine Paugam‐Burtz – 16 July 2010 – Early‐onset hospital‐acquired pneumonia (E‐HAP) is one of the leading causes of sepsis and mortality after liver transplantation (LT). The appropriate antimicrobial therapy is crucially important for surviving sepsis in this context. The aim of this study was to analyze microbiological findings, associated factors, and optimal antibiotic regimens for E‐HAP after LT.

John D. Ryan, Eleanor Ryan, Aurelie Fabre, Matthew W. Lawless, John Crowe – 30 June 2010 – Hereditary hemochromatosis (HH) is a common inherited iron overload disorder. The vast majority of patients carry the missense Cys282Tyr mutation of the HFE gene. Hepcidin, the central regulator of iron homeostasis, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload. The bone morphogenic protein (BMP)/small mothers against decapentaplegic (Smad) signaling cascade is central to the regulation of hepcidin.

Fred Poordad, Eric Lawitz, Mitchell L. Shiffman, Tarek Hassanein, Andrew J. Muir, Bruce R. Bacon, Jamie Heise, Deanine Halliman, Eric Chun, Janet Hammond – 30 June 2010 – Ribavirin‐induced hemolytic anemia can prompt dose reductions and lower sustained virologic response (SVR) rates in the treatment of patients with chronic hepatitis C. The study aimed to determine if weight‐based dosing of taribavirin (TBV), an oral prodrug of ribavirin (RBV), demonstrated efficacy comparable to RBV while maintaining its previously demonstrated anemia advantage with fixed dose administration. A U.S.