Early diagnosis of primary nonfunction and indication for reoperation after liver transplantation

Johan Friso Lock, Eugen Schwabauer, Peter Martus, Nikolay Videv, Johann Pratschke, Maciej Malinowski, Peter Neuhaus, Martin Stockmann – 26 January 2010 – Initial graft function is a major factor influencing the clinical outcome after liver transplantation (LTX), but a reliable method for assessing and predicting graft dysfunction directly after LTX is not available.

Impact of pretransplant infections on clinical outcomes of liver transplant recipients

Hsin‐Yun Sun, Thomas V. Cacciarelli, Nina Singh – 26 January 2010 – Whether pretransplant nonviral infections influence outcomes after transplantation in liver transplant recipients in the current era is not well defined. One hundred consecutive patients undergoing liver transplantation in 2005‐2008 were studied. Demographics, posttransplant clinical events, and mortality were compared between recipients with and without infections within 12 months before transplantation.

Complement component C3 allotypes and outcomes in liver transplantation

Navdeep Dhillon, Liron Walsh, Bernd Krüger, Anita Mehrotra, Stephen C. Ward, Jim Godbold, Mohamed Radwan, Thomas Schiano, Barbara Murphy, Bernd Schröppel – 26 January 2010 – The complement system has been implicated in the pathogenesis of liver diseases. Human complement component C3 (C3) exists as 2 allotypes, fast (F) and slow (S). We conducted a study to address the influence of these alleles on ischemia‐reperfusion (IR) injury and graft survival in liver transplant recipients. Four hundred thirty patients receiving liver transplants from 2000 to 2004 were included.

Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation

Claire Terry, Anil Dhawan, Ragai R. Mitry, Sharon C. Lehec, Robin D. Hughes – 26 January 2010 – Cryopreservation of human hepatocytes is important for their use in hepatocyte transplantation. On thawing, cryopreserved hepatocytes often have reduced viability and metabolic function in comparison with fresh cells. The aim of this study was to modify the different steps in the standard cryopreservation procedure in an attempt to improve the overall outcome. Human hepatocytes with a viability of 69% ± SD 16% were isolated from donor livers with a collagenase perfusion technique.

Induced tolerance to rat liver allografts involves the apoptosis of intragraft T cells and the generation of CD4+CD25+FoxP3+ T regulatory cells

Masato Fujiki, Carlos O. Esquivel, Olivia M. Martinez, Samuel Strober, Shinji Uemoto, Sheri M. Krams – 26 January 2010 – Posttransplant total lymphoid irradiation is a nonmyeloablative regimen that has been extensively studied in rodent models for the induction of tolerance to bone marrow and solid organ allografts. Previous studies of experimental models and clinical transplantation have used total lymphoid irradiation in combination with anti‐lymphocyte–depleting reagents and donor cell infusion to promote graft acceptance.

Bone marrow‐derived stem cells in liver repair: 10 years down the line

Eleanor S. Gilchrist, John N. Plevris – 26 January 2010 – Hematopoietic stem cells have potential in the field of regenerative medicine because of their capacity to form cells of different lineages. Bone marrow stem cells have been shown to contribute to parenchymal liver cell populations, and although this may not be functionally significant, it has sparked interest in the field of autologous stem cell infusion as a possible treatment for cirrhosis.

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