Generation of endoderm‐derived human induced pluripotent stem cells from primary hepatocytes

Hua Liu, Zhaohui Ye, Yonghak Kim, Saul Sharkis, Yoon‐Young Jang – 22 April 2010 – Recent advances in induced pluripotent stem (iPS) cell research have significantly changed our perspective on regenerative medicine. Patient‐specific iPS cells have been derived not only for disease modeling but also as sources for cell replacement therapy. However, there have been insufficient data to prove that iPS cells are functionally equivalent to human embryonic stem (hES) cells or are safer than hES cells.

Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell–specific signal transducer and activator of transcription 3 gene knockout mice

Norio Horiguchi, Fouad Lafdil, Andrew M. Miller, Ogyi Park, Hua Wang, Mohanraj Rajesh, Partha Mukhopadhyay, Xin Yuan Fu, Pal Pacher, Bin Gao – 22 April 2010 – Liver injury is associated with inflammation, which is generally believed to accelerate the progression of liver diseases; however, clinical data show that inflammation does not always correlate with hepatocelluar damage in some patients.

Characterization of the middle hepatic artery and its relevance to living donor liver transplantation

Shaofa Wang, Xiaoshun He, Ziping Li, Zhenpeng Peng, Nga Lei Tam, Canhui Sun, Anbin Hu, Jiefu Huang – 13 April 2010 – In comparison with the left and right hepatic arteries, there is a relative lack of information on the middle hepatic artery (MHA). In this study, data obtained by multidetector computed tomography from 145 patients were studied to evaluate anatomical variations of the MHA, a hilar artery that primarily supplies hepatic segment 4. An MHA was present in 103 (71%) of the subjects.

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