Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma

Dongyao Wang, Huiwen Wu, Jianxin Yang, Min Li, Changquan Ling, Zelong Gao, Hongtao Lu, Hui Shen, Yuxiao Tang – 9 July 2022 – It is interesting that high iron is an independent inducer or cofactor of hepatocellular carcinoma (HCC) while the amount of iron is decreased in the liver tumor tissues. Due to the previous findings that iron deficiency promoted HCC metastasis, it is of significance to identify the underlying mechanism of iron deficiency in HCC. The tumor iron content and expressions of iron‐metabolic molecules were observed in the primary liver cancers of rats and mice.

Alpha‐fetoprotein slope over 7.5 ng/ml over 3 months before liver transplantation for hepatocellular carcinoma predicts recurrence even after controlling for alpha‐fetoprotein at liver transplantation

Machine learning models are superior to noninvasive tests in identifying clinically significant stages of NAFLD and NAFLD‐related cirrhosis

Devon Chang, Emily Truong, Edward A. Mena, Fabiana Pacheco, Micaela Wong, Maha Guindi, Tsuyoshi T. Todo, Nabil Noureddin, Walid Ayoub, Ju Dong Yang, Irene K. Kim, Anita Kohli, Naim Alkhouri, Stephen Harrison, Mazen Noureddin – 8 July 2022

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