Acute hemodynamic response to propranolol predicts bleeding and nonbleeding decompensation in patients with cirrhosis
Benedikt S. Hofer, Benedikt Simbrunner, David J. M. Bauer, Rafael Paternostro, Philipp Schwabl, Bernhard Scheiner, Georg Semmler, Lukas Hartl, Mathias Jachs, Barbara Datterl, Albert F. Staettermayer, Michael Trauner, Mattias Mandorfer, Thomas Reiberger – 7 July 2022 – Nonselective beta‐blockers are used as prophylaxis for variceal bleeding in patients with advanced chronic liver disease (ACLD). The acute hemodynamic response to intravenous propranolol (i.e., ≥10% reduction in hepatic venous pressure gradient [HVPG]) is linked to a decreased risk of variceal bleeding.
Letter to the editor: Low sensitivity of RT‐Alu‐PCR in detection of HBV integrated chimeric transcripts
Abudurexiti Abulaiti, Zhiqiang Gu, Qianqian Jiang, Hongxin Huang, Fengmin Lu – 7 July 2022
Less is more? Screening for steatosis in older populations
Hannes Hagström, Ying Shang – 7 July 2022
Mast cells selectively target large cholangiocytes during biliary injury via H2HR‐mediated cAMP/pERK1/2 signaling
Tianhao Zhou, Vik Meadows, Debjyoti Kundu, Konstantina Kyritsi, Travis Owen, Ludovica Ceci, Guido Carpino, Paolo Onori, Eugenio Gaudio, Nan Wu, Shannon Glaser, Burcin Ekser, Gianfranco Alpini, Lindsey Kennedy, Heather Francis – 6 July 2022 – Bile ducts are heterogenous in structure and function, and primary sclerosing cholangitis (PSC) damages specific bile ducts leading to ductular reaction (DR), mast cell (MC) infiltration, increased histamine release, inflammation, and fibrosis.
RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling
Yanqiu Zhang, Shengtao Ye, Weijia Lu, Jiawen Zhong, Yingrong Leng, Ting Yang, Jun Luo, Wenjun Xu, Hao Zhang, Lingyi Kong – 6 July 2022
The emotional burden of caregiving for patients with cirrhosis
Zachary M. Saleh, Najat E. Salim, Samantha Nikirk, Marina Serper, Elliot B. Tapper – 5 July 2022 – Caregivers for patients with cirrhosis face immense physical and psychological strain that negatively impact quality of life and ability to care for oneself. The aim is to explore the caregiver experience for patients with cirrhosis, identify prominent stressors, and understand the multidimensional contributors to caregiver burden, to help tailor effective interventions.
Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària – 4 July 2022
Letter to the editor: l‐ornithine l‐aspartate in acute treatment of severe hepatic encephalopathy: A double‐blind randomized controlled trial
Alexander J. Kovalic, Tai‐Ping Lee, Ben L. Da – 4 July 2022