Logistical burden of offers and allocation inefficiency in circle‐based liver allocation

Nicholas L. Wood, Douglas N. VanDerwerken, Dorry L. Segev, Sommer E. Gentry – 12 June 2022 – Recent changes to liver allocation replaced donor service areas with circles as the geographic unit of allocation. Circle‐based allocation might increase the number of transplantation centers and candidates required to place a liver, thereby increasing the logistical burden of making and responding to offers on organ procurement organizations and transplantation centers.

Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2−/− mouse model of sclerosing cholangitis via immunomodulatory effects

Claudia D. Fuchs, Emmanuel D. Dixon, Tim Hendrikx, Veronika Mlitz, Annika Wahlström, Marcus Ståhlman, Hubert Scharnagl, Tatjana Stojakovic, Christoph J. Binder, Hanns‐Ulrich Marschall, Michael Trauner – 11 June 2022 – Bile salt export pump (Bsep) (Abcb11)−/− mice are protected from acquired cholestatic injury due to metabolic preconditioning with a hydrophilic bile acid (BA) pool with formation of tetrahydroxylated bile acids (THBAs).

A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

Ariunaa Sumiyadorj, Kazuhisa Murai, Tetsuro Shimakami, Kazuyuki Kuroki, Tomoki Nishikawa, Masaki Kakuya, Atsumu Yamada, Ying Wang, Atsuya Ishida, Takayoshi Shirasaki, Shotaro Kawase, Ying‐Yi Li, Hikari Okada, Kouki Nio, Kazunori Kawaguchi, Taro Yamashita, Yoshio Sakai, Davaadorj Duger, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko – 11 June 2022 – For the development of antiviral agents to eliminate hepatitis B virus (HBV), it is essential to establish an HBV cell culture system that can easily monitor HBV infection.

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