Bile duct anastomosis does not promote bacterial contamination of autologous blood salvaged during living donor liver transplantation

Doyeon Kim, Sangbin Han, You Sang Kim, Gyu‐Sung Choi, Jong Man Kim, Kyo Won Lee, Jae‐Hoon Ko, In Young Yoo, Justin Sangwook Ko, Mi Sook Gwak, Jae‐Won Joh, Gaab Soo Kim – 9 June 2022 – Bile duct surgeries are conventionally considered to promote bacterial contamination of the surgical field. However, liver transplantation recipients' bile produced by the newly implanted liver graft from healthy living donors may be sterile. We tested bacterial contamination of autologous blood salvaged before and after bile duct anastomosis (BDA) during living donor liver transplantation (LDLT).

A prospective investigation of serum bile acids with risk of liver cancer, fatal liver disease, and biliary tract cancer

Zeinab Farhat, Neal D. Freedman, Joshua N. Sampson, Roni T. Falk, Jill Koshiol, Stephanie J. Weinstein, Demetrius Albanes, Rashmi Sinha, Erikka Loftfield – 7 June 2022 – Bile acids (BAs), major regulators of the gut microbiota, may play an important role in hepatobiliary cancer etiology. However, few epidemiologic studies have comprehensively examined associations between BAs and liver or biliary tract cancer.

Impact of long‐term administration of maralixibat on children with cholestasis secondary to Alagille syndrome

Benjamin L. Shneider, Catherine A. Spino, Binita M. Kamath, John C. Magee, Rosalinda V. Ignacio, Suiyuan Huang, Simon P. Horslen, Jean P. Molleston, Alexander G. Miethke, Rohit Kohli, Daniel H. Leung, M. Kyle Jensen, Kathleen M. Loomes, Saul J. Karpen, Cara Mack, Philip Rosenthal, Robert H. Squires, Alastair Baker, Sanjay Rajwal, Deirdre Kelly, Ronald J. Sokol, Richard J. Thompson, for ChiLDReN and UK IMAGO/IMAGINE Investigators – 6 June 2022 – There is growing interest in, but limited data about, intestinal bile acid transport inhibitors as treatment for cholestatic liver disease.

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