Verena Keitel, Martin Burdelski, Zsuzsanna Vojnisek, Lutz Schmitt, Dieter Häussinger, Ralf Kubitz – 29 July 2009 – Progressive familial intrahepatic cholestasis type 2 (PFIC‐2) is caused by mutations of the bile salt export pump (BSEP [ABCB11]), an ATP‐binding cassette (ABC)‐transporter exclusively expressed at the canalicular membrane of hepatocytes. An absence of BSEP from the canalicular membrane causes cholestasis and leads to liver cirrhosis, which may necessitate liver transplantation in early childhood.

Anna Alisi, Rita Devito, Valerio Nobili – 29 July 2009

Zoe A. Stewart, Jayme E. Locke, Robert A. Montgomery, Andrew L. Singer, Andrew M. Cameron, Dorry L. Segev – 29 July 2009 – In the United States, ABO‐incompatible liver transplantation (ILT) is limited to emergent situations when ABO‐compatible liver transplantation (CLT) is unavailable. We analyzed the United Network for Organ Sharing database of ILT performed from 1990‐2006 to assess ILT outcomes for infant (0‐1 years; N = 156), pediatric (2‐17 years; N = 170), and adult (> 17 years; N = 667) patients.

Richard B. Freeman – 29 July 2009

Kevin T. Shiley, Leanne B. Gasink, Todd D. Barton, Patrice Pfeiffenberger, Kim M. Olthoff, Emily A. Blumberg – 29 July 2009 – Optimal measures for the prevention of cytomegalovirus (CMV) in high‐risk orthotopic liver transplant (OLT) patients are unknown. The charts of high‐risk OLT recipients with 12 months of follow‐up who were transplanted over a 44‐month period were reviewed. The incidence of CMV disease in CMV‐seropositive donor/CMV‐seronegative recipient patients receiving valganciclovir or ganciclovir prophylaxis was compared.

Yoichiro Uchida, Maria Cecilia S. Freitas, Danyun Zhao, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 29 July 2009 – Neutrophils are considered crucial effector cells in the pathophysiology of organ ischemia/reperfusion injury (IRI). Although neutrophil elastase (NE) accounts for a substantial portion of the neutrophil activity, the function of NE in liver IRI remains unclear. This study focuses on the role of NE in the mechanism of liver IRI.

Holenarasipur R. Vikram, Shimon Kusne – 29 July 2009

James D. Perkins – 29 July 2009

Paul J. Thuluvath – 29 July 2009

Gregory A. Eschenauer, Simon W. Lam, Peggy L. Carver – 29 July 2009 – Although the overall incidence of fungal infections in liver transplant recipients has declined, these infections still contribute significantly to the morbidity and mortality of patients with risk factors for infection. Although antifungal prophylaxis has been widely studied and practiced, no consensus exists on which patients should receive prophylaxis, with which agent, and for what duration.