Portal inflammation as index of steatohepatitis in children with nonalcoholic fatty liver disease
Anna Alisi, Rita Devito, Valerio Nobili – 29 July 2009
ABO‐incompatible deceased donor liver transplantation in the United States: A national registry analysis
Zoe A. Stewart, Jayme E. Locke, Robert A. Montgomery, Andrew L. Singer, Andrew M. Cameron, Dorry L. Segev – 29 July 2009 – In the United States, ABO‐incompatible liver transplantation (ILT) is limited to emergent situations when ABO‐compatible liver transplantation (CLT) is unavailable. We analyzed the United Network for Organ Sharing database of ILT performed from 1990‐2006 to assess ILT outcomes for infant (0‐1 years; N = 156), pediatric (2‐17 years; N = 170), and adult (> 17 years; N = 667) patients.
Overcoming the ABO incompatibility barrier
Richard B. Freeman – 29 July 2009
Increased incidence of cytomegalovirus infection in high‐risk liver transplant recipients receiving valganciclovir prophylaxis versus ganciclovir prophylaxis
Kevin T. Shiley, Leanne B. Gasink, Todd D. Barton, Patrice Pfeiffenberger, Kim M. Olthoff, Emily A. Blumberg – 29 July 2009 – Optimal measures for the prevention of cytomegalovirus (CMV) in high‐risk orthotopic liver transplant (OLT) patients are unknown. The charts of high‐risk OLT recipients with 12 months of follow‐up who were transplanted over a 44‐month period were reviewed. The incidence of CMV disease in CMV‐seropositive donor/CMV‐seronegative recipient patients receiving valganciclovir or ganciclovir prophylaxis was compared.
The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion
Yoichiro Uchida, Maria Cecilia S. Freitas, Danyun Zhao, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 29 July 2009 – Neutrophils are considered crucial effector cells in the pathophysiology of organ ischemia/reperfusion injury (IRI). Although neutrophil elastase (NE) accounts for a substantial portion of the neutrophil activity, the function of NE in liver IRI remains unclear. This study focuses on the role of NE in the mechanism of liver IRI.
Mycobacterium tuberculosis infection in immunocompromised hosts: A diagnostic challenge
Holenarasipur R. Vikram, Shimon Kusne – 29 July 2009
Another formula to determine the prognosis of patients with acute liver failure
James D. Perkins – 29 July 2009
Antifungal prophylaxis in liver transplant recipients
Gregory A. Eschenauer, Simon W. Lam, Peggy L. Carver – 29 July 2009 – Although the overall incidence of fungal infections in liver transplant recipients has declined, these infections still contribute significantly to the morbidity and mortality of patients with risk factors for infection. Although antifungal prophylaxis has been widely studied and practiced, no consensus exists on which patients should receive prophylaxis, with which agent, and for what duration.
Identification of microRNA‐181 by genome‐wide screening as a critical player in EpCAM–positive hepatic cancer stem cells
Junfang Ji, Taro Yamashita, Anuradha Budhu, Marshonna Forgues, Hu‐Liang Jia, Cuiling Li, Chuxia Deng, Elaine Wauthier, Lola M. Reid, Qing‐Hai Ye, Lun‐Xiu Qin, Wen Yang, Hong‐Yang Wang, Zhao‐You Tang, Carlo M. Croce, Xin Wei Wang – 29 July 2009 – MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate gene expression with functional links to tumorigenesis. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it is heterogeneous in clinical outcomes and biological activities.