Hepatic failure due to hepatitis B reactivation in a patient with ulcerative colitis treated with prednisone
Jonas Zeitz, Beat Mullhaupt, Heiko Fruehauf, Gerhard Rogler, Stephan R. Vavricka – 29 July 2009
Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity
Bihui Zhong, Pavel Strnad, Carlo Selmi, Pietro Invernizzi, Guo‐Zhong Tao, Angela Caleffi, Minhu Chen, Ilaria Bianchi, Mauro Podda, Antonello Pietrangelo, M. Eric Gershwin, M. Bishr Omary – 29 July 2009 – Keratins (K) 8 and 18 variants predispose carriers to the development of end‐stage liver disease and patients with chronic hepatitis C to disease progression. Hepatocytes express K8/K18, whereas biliary epithelia express K8/K18/K19.
Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver
Ekaterina Breous, Suryanarayan Somanathan, Luk H. Vandenberghe, James M. Wilson – 29 July 2009 – The mechanisms of tolerance in the liver that limit susceptibility to food allergy and that mediate the acceptance of liver transplants, even with a complete major histocompatibility complex (MHC) mismatch, remain poorly defined. Here we report that in a model of liver‐directed gene transfer, cytotoxic T lymphocyte (CTL) responses to non‐self antigens are controlled by hepatic regulatory T cells (Tregs) that secrete the immunosuppressive cytokine interleukin (IL)‐10 in response to the antigen.
An intention‐to‐treat analysis of liver transplantation for hepatocellular carcinoma using organ procurement transplant network data
Shawn J. Pelletier, Sherry Fu, Veena Thyagarajan, Carlos Romero‐Marrero, Mashal J. Batheja, Jeffrey D. Punch, John C. Magee, Anna S. Lok, Robert J. Fontana, Jorge A. Marrero – 29 July 2009 – Single‐center studies have shown acceptable long‐term outcomes following orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) when tumors are within the Milan criteria. However, the overall survival and waiting list removal rates have not been described at a national level with pooled registry data.
Treatment with immunosuppressives in patients with primary biliary cirrhosis who fail to respond to ursodiol
Marshall M. Kaplan, Raoul Poupon – 29 July 2009
Beyond the body surface area vauthey formula to identify the minimal donor volume for right‐lobe living‐donor liver transplantation
Salvatore Gruttadauria, Fabrizio di Francesco, James Wallis Marsh, Amadeo Marcos, Bruno Gridelli – 29 July 2009
Sustained virological response to interferon plus ribavirin reduces liver‐related complications and mortality in patients coinfected with human immunodeficiency virus and hepatitis C virus
Juan Berenguer, Julio Álvarez‐Pellicer, Pilar Miralles Martín, José López‐Aldeguer, Miguel Angel Von‐Wichmann, Carmen Quereda, Josep Mallolas, José Sanz, Cristina Tural, José María Bellón, Juan González‐García, The GESIDA3603/5607 Study Group – 29 July 2009 – Human immunodeficiency virus (HIV) infection modifies the natural history of chronic hepatitis C, thus promoting more rapid progression to cirrhosis and end‐stage liver disease.
Interleukin 27 and viral hepatitis: Smarter than the average cytokine
Arian Laurence, Paul Klennerman – 29 July 2009
Dropping liver fat droplets
Sander Kersten, Michael Müller – 29 July 2009
Prognostic value of computerized quantification of liver fibrosis in children with biliary atresia
Lars Pape, Karen Olsson, Claus Petersen, Reinhard von Wasilewski, Michael Melter – 29 July 2009 – Biliary atresia (BA) is the leading indication for liver transplantation (LTx) during childhood. Predictive markers for progression are lacking. We investigated the correlation between quantified fibrosis of the liver at the time of Kasai hepatic portoenterostomy (KPE) and the clinical course. Liver tissue was obtained at the time of KPE in 53 children and stained with Picrosirius red. The mean volume of fibrosis per number of periportal fields (Vfib) and the Ishak score were calculated.