Amiodarone pretreatment of organ donors exerts anti‐oxidative protection but induces excretory dysfunction in liver preservation and reperfusion
Mohammed Reza Moussavian, Otto Kollmar, Michael Schmidt, Claudia Scheuer, Matthias Wagner, Jan Erik Slotta, Gernot Gronow, Christoph Justinger, Michael Dieter Menger, Martin Karl Schilling – 26 June 2009 – The continuous shortage of organs necessitates the use of marginal organs from donors with various diseases, including arrhythmia‐associated cardiac failure. One of the most frequently used anti‐arrhythmic drugs is amiodarone (AM), which is given in particular in emergency situations. Apart from its anti‐arrhythmic actions, AM provides anti‐oxidative properties in cardiomyocytes.