Geir I. Nedredal, Kjetil Elvevold, Lars M. Ytrebø, Ole‐Martin Fuskevåg, Ingvild Pettersen, Peter A. G. McCourt, Kjell Bertheussen, Bård Smedsrød, Arthur Revhaug – 27 August 2009 – Ammonia metabolism in the liver has been largely credited to hepatocytes (HCs). We have shown that liver nonparenchymal cells that include liver sinusoidal endothelial cells (LSECs) produce ammonia.
Ester Vanni, Maria Lorena Abate, Elena Gentilcore, Ingrid Hickman, Roberto Gambino, Maurizio Cassader, Antonina Smedile, Ele Ferrannini, Mario Rizzetto, Giulio Marchesini, Amalia Gastaldelli, Elisabetta Bugianesi – 27 August 2009 – Chronic hepatitis C (CHC) has been associated with type 2 diabetes and insulin resistance, but the extent of impairment in insulin action, the target pathways involved, and the role of the virus per se have not been defined.
Dhiraj Tripathi, James W. Ferguson, Narendra Kochar, Joanna A. Leithead, George Therapondos, Norma C. Mcavoy, Adrian J. Stanley, Ewan H. Forrest, William S. Hislop, Peter R. Mills, Peter C. Hayes – 27 August 2009 – Current therapy for preventing the first variceal bleed includes beta‐blocker and variceal band ligation (VBL). VBL has lower bleeding rates, with no differences in survival, whereas beta‐blocker therapy can be limited by side effects.
Bruce R. Bacon – 27 August 2009
Anna S. F. Lok, Brian J. McMahon – 27 August 2009
Heike Bantel, Matthias J. Bahr, Klaus Schulze‐Osthoff – 27 August 2009
Fabio Marra, Cristiana Bertolani – 27 August 2009 – Adipokines are polypeptides secreted in the adipose tissue in a regulated manner. While some of these molecules are expressed only by adipocytes, resident and infiltrating macrophages and components of the vascular stroma markedly contribute to expression of other adipokines. As a result, adipose tissue inflammation is associated with a modification in the pattern of adipokine secretion.
Silvia Giugliano, Filiz Oezkan, Mathias Bedrejowski, Markus Kudla, Markus Reiser, Sergei Viazov, Norbert Scherbaum, Michael Roggendorf, Joerg Timm – 27 August 2009 – The inherent sequence diversity of the hepatitis C virus (HCV) with the existence of multiple genotypes that differ up to 20% at the amino acid level represents one of the major obstacles for immune control.
Nimantha De Alwis, Gavin Hudson, Alastair D. Burt, Christopher P. Day, Patrick F. Chinnery – 27 August 2009
Keith D. Lindor, Kris V. Kowdley, Velimir A. C. Luketic, M. Edwyn Harrison, Timothy McCashland, Alex S. Befeler, Denise Harnois, Roberta Jorgensen, Jan Petz, Jill Keach, Jody Mooney, Carol Sargeant, Julie Braaten, Tamara Bernard, Debra King, Ellen Miceli, Jeff Schmoll, Tanya Hoskin, Prabin Thapa, Felicity Enders – 27 August 2009 – Previous controlled trials are inconclusive regarding the efficacy of ursodeoxycholic acid (UDCA) for treating primary sclerosing cholangitis (PSC).