Effects of satavaptan, a selective vasopressin V2 receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial

Pere Ginès, Florence Wong, Hugh Watson, Slobodan Milutinovic, Luis Ruiz del Arbol, Dan Olteanu, HypoCAT study investigators – 20 June 2008 – Hyponatremia in cirrhosis is associated with significant morbidity and mortality and complicates ascites management. Vasopressin receptor antagonists improve serum sodium concentration by increasing renal solute‐free water excretion, but their effects on the management of ascites have not been assessed.

The molecular mechanism regulating 24‐hour rhythm of CYP2E1 expression in the mouse liver

Naoya Matsunaga, Misaki Ikeda, Takako Takiguchi, Satoru Koyanagi, Shigehiro Ohdo – 20 June 2008 – Cytochrome P450 2E1 (CYP2E1) is clinically and toxicologically important and exhibits 24‐hour periodicity in its activity. In the present study, we investigated whether hepatic nuclear factor‐1α (HNF‐1α) and clock genes with a striking 24‐hour rhythm in mouse liver contributed to the 24‐hour regulation of CYP2E1 expression. The results demonstrated that the expression of CYP2E1 messenger RNA (mRNA) in the liver was affected by HNF‐1α and the circadian organization of molecular clocks.

Trends in mortality from hepatocellular carcinoma in Europe, 1980‐2004

Cristina Bosetti, Fabio Levi, Paolo Boffetta, Franca Lucchini, Eva Negri, Carlo La Vecchia – 20 June 2008 – Upward trends in mortality from hepatocellular carcinoma (HCC) were recently reported in the United States and Japan. Comprehensive analyses of most recent data for European countries are not available. Age‐standardized (world standard) HCC rates per 100,000 (at all ages, at age 20‐44, and age 45‐59 years) were computed for 23 European countries over the period 1980‐2004 using data from the World Health Organization.

Granulocyte‐colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: A randomized trial

Laurent Spahr, Jean‐François Lambert, Laura Rubbia‐Brandt, Yves Chalandon, Jean‐Louis Frossard, Emiliano Giostra, Antoine Hadengue – 20 June 2008 – Liver failure is the major cause of death in alcoholic steatohepatitis (ASH). In experimental hepatitis, granulocyte‐colony stimulating factor (G‐CSF) mobilizes hematopoietic stem cells, induces liver regeneration, and improves survival. We studied the short‐term effects of G‐CSF on CD34+ stem cell mobilization, liver cell proliferation, and liver function in patients with ASH.

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