Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice

Jeehee Kim, Mihwa Kim, Joseph H. Song, H. Thomas Lee – 28 May 2008 – Hepatic ischemia reperfusion (IR) injury is a major clinical problem during the perioperative period and occurs frequently after major hepatic resection or liver transplantation. Exogenous and endogenous A1 adenosine receptor (A1AR) activation protects against renal IR injury. In this study, we questioned whether exogenous and endogenous A1AR activation protects against hepatic IR injury in vivo. A1AR wild‐type (WT) or knockout mice were subjected to 60 minutes of partial hepatic IR.

Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopic liver transplant

Angel Asensio, Antonio Ramos, Valentin Cuervas‐Mons, Elisa Cordero, Victor Sánchez‐Turrión, Marino Blanes, Carlos Cervera, Joan Gavalda, Jose M. Aguado, Julian Torre‐Cisneros – 28 May 2008 – Surgical site infections are common bacterial infections in orthotopic liver transplantation. The purpose of this study was to determine the incidence, timing, location, and risk factors, specifically antibiotic prophylaxis, for surgical site infections.

Liver transplantation for subacute hepatocellular failure due to massive steatohepatitis after bariatric surgery

Luiz Augusto Carneiro D'Albuquerque, Adriano Miziara Gonzalez, Raul Carlos Wahle, Evandro de Oliveira Souza, Jorge Marcelo Padilla Mancero, Adávio de Oliveira e Silva – 28 May 2008 – New therapeutic options for obesity include restrictive bowel surgery and surgery that promotes malabsorption, such as the Fobi‐Capella (gastric bypass) and Scopinaro (biliopancreatic diversion) techniques. Complications associated with these procedures, such as hepatocellular failure, have been observed with increasing frequency.

The prevalence of a heparin‐like effect shown on the thromboelastograph in patients undergoing liver transplantation

Seema Agarwal, Marco Senzolo, Clare Melikian, Andrew Burroughs, Susan V. Mallett – 28 May 2008 – It has been known for several decades that thromboelastographic analysis of the blood of patients undergoing liver transplantation may show a heparin‐like effect (HLE) at the time of reperfusion. However, the prevalence of HLE and the origin of these heparin‐like substances remain largely unstudied.

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