25 February 2009

Ying Luo, Chung Mau Lo, Cindy K. Cheung, George K. Lau, John Wong – 25 February 2009 – Cellular immunity plays an important role in the long‐term control of hepatitis B virus (HBV) infection. We studied the changes in HBV‐specific CD4 T cell immunity after orthotopic liver transplantation (OLT) for chronic hepatitis B under antiviral prophylaxis.

Jörg Schrader, Jonathan Fallowfield, John P. Iredale – 25 February 2009

Johan Ungerstedt, Greg Nowak, Urban Ungerstedt, Bo‐Göran Ericzon – 25 February 2009 – Early detection of vascular complications following liver surgery is crucial. In the present study, intrahepatic microdialysis was used for continuous monitoring of porcine liver metabolism during occlusion of either the portal vein or the hepatic artery. Our aim was to assess whether microdialysis can be used to detect impaired vascular inflow by metabolic changes in the liver. Changes in metabolite concentrations in the hepatic interstitium were taken as markers for metabolic changes.

Edward Alabraba, Peter Nightingale, Bridget Gunson, Stefan Hubscher, Simon Olliff, Darius Mirza, James Neuberger – 25 February 2009 – Previously, we have found that the absence of the colon after liver transplantation (LT) protects the patient from recurrent primary sclerosing cholangitis (rPSC). As our previous observation has not been confirmed in other series, we have reviewed our cohort of patients grafted for primary sclerosing cholangitis (PSC) with greater numbers and longer follow‐up to reassess the rate, consequences, and risk factors for rPSC.

Susagna Padrissa‐Altés, Rosa Franco‐Gou, Olivier Boillot, Anna Serafín, Antoni Rimola, Vicente Arroyo, Joan Rodés, Carmen Peralta, Joan Roselló‐Catafau – 25 February 2009 – This study examined whether angiotensin II (Ang II) blockers [Ang II type I receptor antagonist, Ang II type II receptor antagonist, and angiotensin converting enzyme (ACE) inhibitor] could reduce hepatic injury and improve regeneration in reduced‐size orthotopic liver transplantation (ROLT) and whether the beneficial effects of ischemic preconditioning (PC) in ROLT could be explained by changes in Ang II.

Anne Marie Roque‐Afonso – 25 February 2009

Xiangbin Xing, Elke Burgermeister, Fabian Geisler, Henrik Einwächter, Lian Fan, Michaela Hiber, Sandra Rauser, Axel Walch, Christoph Röcken, Martin Ebeling, Matthew B. Wright, Roland M. Schmid, Matthias P.A. Ebert – 24 February 2009 – Farnesoid X receptor (FXR/Fxr) is a bile acid–regulated nuclear receptor that promotes hepatic bile acid metabolism, detoxification, and liver regeneration. However, the adaptive pathways under conditions of bile acid stress are not fully elucidated.

Heping Yang, Tony W. H. Li, Kwang Suk Ko, Meng Xia, Shelly C. Lu – 24 February 2009 – Toxic bile acids induce hepatocyte apoptosis, for which p53 and cyclin D1 have been implicated as underlying mediators. Both p53 and cyclin D1 are targets of c‐Myc, which is also up‐regulated in cholestasis. Myc and Mnt use Max as a cofactor for DNA binding. Myc‐Max typically activates transcription via E‐box binding. Mnt‐Max also binds the E‐box sequence but serves as a repressor and inhibits the enhancer activity of Myc‐Max.

Elizabeth M. Brunt, David E. Kleiner, Laura A. Wilson, Aynur Unalp, Cynthia E. Behling, Joel E. Lavine, Brent A. Neuschwander‐Tetri, NASH Clinical Research Network – 24 February 2009 – Adult nonalcoholic fatty liver disease (NAFLD) is characterized by absent or mild portal chronic inflammation (CI); in children, portal CI may be predominant. This study correlated clinical features with portal CI. Centrally‐graded biopsies and temporally‐related clinical parameters from 728 adults and 205 children. From the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) were evaluated.