Safety and efficacy of the percutaneous treatment of bile leaks in hepaticojejunostomy or split‐liver transplantation without dilatation of the biliary tree

Dorico Righi, Alessandro Franchello, Alessandro Ricchiuti, Andrea Doriguzzi Breatta, Karine Versace, Amedeo Calvo, Renato Romagnoli, P. Fonio, Giovanni Gandini, Mauro Salizzoni – 23 April 2008 – Biliary leaks complicating hepaticojejunostomy (HJA) or fistulas from cut surface are severe complications after liver transplantation (LT) and split‐liver transplantation (SLT). The aim of the study was to describe our experience about the safety and efficacy of radiological percutaneous treatment without dilatation of intrahepatic biliary ducts.

Rapid evolution of congenital hepatic fibrosis after liver transplantation for acute liver failure: The potential role of extrahepatic factors

Judith Flores, Ronen Arnon, Raffaella A. Morotti, Lisa Guay‐Woodford, Sukru Emre, Benjamin L. Shneider – 23 April 2008 – A 9‐year‐old male underwent deceased donor liver transplantation for idiopathic fulminant hepatic failure. In the postoperative period, a review of perioperative biopsies of the donor liver revealed mild features of congenital hepatic fibrosis. Over the ensuing year, the recipient developed severe complications of congenital hepatic fibrosis including multiple episodes of cholangitis and progressive portal hypertension.

The prevalence and natural history of untreated isolated central perivenulitis in adult allograft livers

Alyssa M. Krasinskas, A. Jake Demetris, John J. Poterucha, Susan C. Abraham – 23 April 2008 – Central perivenulitis (CP) in the allograft liver can be associated with portal‐based acute cellular rejection and autoimmune hepatitis or can occur in isolation (isolated CP). Although several studies have demonstrated the significance of CP, the prevalence and natural history of untreated isolated CP have not been well studied. We examined 100 adult allograft liver recipients who had long‐term follow‐up, had routine protocol biopsies, and received no treatment for isolated CP.

A novel role for adiponectin in regulating the immune responses in chronic hepatitis C virus infection

Clovis Palmer, Taline Hampartzoumian, Andrew Lloyd, Amany Zekry – 21 April 2008 – Adipose tissue releases pro‐inflammatory and anti‐inflammatory mediators, including adiponectin, which elicit a broad range of metabolic and immunological effects. The study aim was to determine in subjects infected with chronic hepatitis C virus (HCV) the effects of total adiponectin and its high‐molecular‐weight (HMW) and low‐molecular‐weight isoforms on HCV‐specific immune responses. Serum levels of total adiponectin and its isoforms were determined by immunoassay.

Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance

Scott Preiss, Margaret Littlejohn, Peter Angus, Alex Thompson, Paul Desmond, Sharon R. Lewin, Joe Sasadeusz, Gail Matthews, Gregory J. Dore, Tim Shaw, Vitini Sozzi, Lilly Yuen, George Lau, Anna Ayres, Chloe Thio, Anchalee Avihingsanon, Kiat Ruxrungtham, Stephen Locarnini, Peter A. Revill – 21 April 2008 – Defective hepatitis B virus DNA (dDNA) is reverse‐transcribed from spliced hepatitis B virus (HBV) pregenomic messenger RNA (pgRNA) and has been identified in patients with chronic HBV (CH‐B).

Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice

Mauricio Berriel Diaz, Anja Krones‐Herzig, Dagmar Metzger, Anja Ziegler, Alexandros Vegiopoulos, Martin Klingenspor, Karin Müller‐Decker, Stephan Herzig – 18 April 2008 – In mammals, triglycerides (TG) represent the most concentrated form of energy. Aberrant TG storage and availability are intimately linked to the negative energy balance under severe clinical conditions, such as starvation, sepsis, or cancer cachexia. Despite its crucial role for energy homeostasis, molecular key determinants of TG metabolism remain enigmatic.

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