Marked regression of abdominal fat amyloid in patients with familial amyloid polyneuropathy during long‐term follow‐up after liver transplantation

Ayako Tsuchiya, Masahide Yazaki, Fuyuki Kametani, Yo‐ichi Takei, Shu‐ichi Ikeda – 26 March 2008 – To elucidate whether the amount of tissue‐deposited amyloid in familial amyloid polyneuropathy (FAP) patients decreases or increases over the long‐term course after liver transplantation (LT), we examined changes in histopathological and biochemical characteristics of abdominal fat amyloid in the transplanted patients with a postoperative history of more than 10 years.

Audiometric changes in patients undergoing liver transplantation using distinct immunosuppressive protocols

Maria Elena Fortes, Cláudio Augusto Marroni, Pedro Luis Coser, Carlos Abaeté de los Santos – 26 March 2008 – The aim of the study was to disclose a possible association of hearing defects with the use of either cyclosporin (CyA) or tacrolimus (FK‐506) in patients undergoing liver transplantation (LT). Pure‐tone audiometry (PTA) was performed in the same 42 patients before and after LT. Audiometric frequencies recorded ranged from 250 to 8000 Hz. Patients were divided into 2 groups according to the use of CyA (n = 18) or FK‐506 (n = 24).

Correlation between the liver temperature employed during machine perfusion and reperfusion damage: Role of Ca2+

Mariapia Vairetti, Andrea Ferrigno, Vittoria Rizzo, Eleonora Boncompagni, Amedeo Carraro, Enrico Gringeri, Gloria Milanesi, Sergio Barni, Isabel Freitas, Umberto Cillo – 26 March 2008 – This study compares the effects of machine perfusion (MP) at different temperatures with simple cold storage. In addition, the role of Ca2+ levels in the MP medium was evaluated. For MP, rat livers were perfused for 6 hours with Krebs‐Henseleit (KH) solution (with 1.25 or 2.5 mM CaCl2) at 4°C, 10°C, 20°C, 25°C, 30°C, or 37°C.

Value of an individual liver biopsy in the preoperative evaluation of apparently healthy potential liver donors

Nurten Savas, Mehmet Coskun, Banu Bilezikci, Irfan Uruc, Hamdi Karakayali, Ugur Yilmaz, Mehmet Haberal – 26 March 2008 – Living donor liver transplantation has acquired widespread acceptance. A thorough workup of the potential living donor is guided by 2 objectives: the first is ensuring the safety of the surgical procedure for the donor, and the second is identifying donor grafts that pose potential risks for the recipient. Of 305 living‐related liver donors, liver biopsy was performed in 201.

Antibody to hepatitis B surface antigen trough levels and half‐lives do not differ after intravenous and intramuscular hepatitis B immunoglobulin administration after liver transplantation

Nazanin Hooman, Kinan Rifai, Johannes Hadem, Bernhard Vaske, Gunnar Philipp, Andrea Priess, Juergen Klempnauer, Hans L. Tillmann, Michael P. Manns, Jens Rosenau – 26 March 2008 – Hepatitis B immunoglobulin (HBIG) administration remains an essential component of standard reinfection prophylaxis after liver transplantation for hepatitis B virus–related liver disease. Previous studies have suggested that intramuscular (IM) HBIG administration compared to intravenous (IV) HBIG administration may be cost‐effective and dose‐saving.

The impact of postreperfusion syndrome on short‐term patient and liver allograft outcome in patients undergoing orthotopic liver transplantation

Ibtesam Hilmi, Charles N. Horton, Raymond M. Planinsic, Tetsuro Sakai, Ramona Nicolau‐Raducu, Daniela Damian, Silivu Gligor, Amadeo Marcos – 26 March 2008 – The greatest part of liver allograft injury occurs during reperfusion, not during the cold ischemia phase. The aim of this study, therefore, was to investigate how the severity of postreperfusion syndrome (PRS) influences short‐term outcome for the patient and for the liver allograft. Over a 2‐year period, 338 consecutive patients who presented for orthotopic liver transplantation (OLT) were included in this retrospective study.

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