Steroid‐free, tacrolimus‐basiliximab immunosuppression in pediatric liver transplantation: Clinical and pharmacoeconomic study in 50 children

Jérémie M. Gras, Sophie Gerkens, Claire Beguin, Magdalena Janssen, Françoise Smets, Jean‐Bernard Otte, Etienne Sokal, Raymond Reding – 26 March 2008 – Corticosteroid‐free immunosuppression (IS) may be potentially beneficial for transplanted patients, particularly children. The purpose of this study was to evaluate the efficacy and cost of such strategy in primary pediatric liver transplantation (LT). Fifty pediatric LT recipients were prospectively treated with a steroid‐free, tacrolimus‐basiliximab–based IS (group TB).

Liver xenografts for the treatment of acute liver failure: Clinical and experimental experience and remaining immunologic barriers

Hidetaka Hara, Bruno Gridelli, Yih Jyh Lin, Amadeo Marcos, David K. C. Cooper – 26 March 2008 – A critical element restricting the application of liver transplantation is the shortage of human deceased donor organs. Xenotransplantation using pig organs might be a solution to this shortage.

Peroxisome proliferator‐activated receptor‐δ induces insulin‐induced gene‐1 and suppresses hepatic lipogenesis in obese diabetic mice

Xiaomei Qin, Xuefen Xie, Yanbo Fan, Jianwei Tian, Youfei Guan, Xian Wang, Yi Zhu, Nanping Wang – 24 March 2008 – Primary nonalcoholic fatty liver disease is one of the most common forms of chronic liver diseases and is associated with insulin‐resistant states such as diabetes and obesity. Recent work has revealed potential implications of peroxisome proliferator‐activated receptor‐δ (PPARδ) in lipid homeostasis and insulin resistance.

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