Corrections
24 November 2008
Is there disease progression in patients who are hepatitis C virus antibody–positive and hepatitis C virus RNA–seronegative?
Russell H. Wiesner – 24 November 2008
Ca2+‐dependent protein kinase C isoforms are critical to estradiol 17β‐D‐glucuronide–induced cholestasis in the rat
Fernando A. Crocenzi, Enrique J. Sánchez Pozzi, María Laura Ruiz, Andrés E. Zucchetti, Marcelo G. Roma, Aldo D. Mottino, Mary Vore – 24 November 2008 – The endogenous estradiol metabolite estradiol 17β‐D‐glucuronide (E217G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt export pump (Bsep, Abcc11) and multidrug resistance‐associated protein 2 (Mrp2, Abcc2) and their associated loss of function.
Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors
Haruaki Shirakawa, Akihiro Matsumoto, Satoru Joshita, Michiharu Komatsu, Naoki Tanaka, Takeji Umemura, Tetsuya Ichijo, Kaname Yoshizawa, Kendo Kiyosawa, Eiji Tanaka, Nagano Interferon Treatment Research Group – 24 November 2008 – The interferon sensitivity determining region (ISDR) of the hepatitis C virus (HCV) and T‐helper type 1 and type 2 (Th1/Th2) ratio were analyzed along with other host and viral factors for their ability to predict the response of patients with chronic hepatitis C to pegylated interferon alpha‐2b (Peg‐IFN) and ribavirin (RBV) combination therapy.
Superoxide produced by Kupffer cells is an essential effector in concanavalin A–induced hepatitis in mice
Hiroyuki Nakashima, Manabu Kinoshita, Masahiro Nakashima, Yoshiko Habu, Satoshi Shono, Takefumi Uchida, Nariyoshi Shinomiya, Shuhji Seki – 24 November 2008 – Although concanavalin A (Con‐A)‐induced experimental hepatitis is thought to be induced by activated T cells, natural killer T (NKT) cells, and cytokines, precise mechanisms are still unknown. In the current study, we investigated the roles of Kupffer cells, NKT cells, FasL, tumor necrosis factor (TNF), and superoxide in Con‐A hepatitis in C57BL/6 mice.
Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
Onpan Cheung, Puneet Puri, Christoph Eicken, Melissa J. Contos, Faridoddin Mirshahi, James W. Maher, John M. Kellum, Haeki Min, Velimir A. Luketic, Arun J. Sanyal – 24 November 2008 – The expression of microRNA in nonalcoholic steatohepatitis (NASH) and their role in the genesis of NASH are not known.
Liver stiffness is an unreliable marker of liver fibrosis in patients with cardiac insufficiency
Pascal Lebray, Shaïda Varnous, Fréderic Charlotte, Anne Varaut, Thierry Poynard, Vlad Ratziu – 24 November 2008
Reply:
Guilherme M. Campos – 24 November 2008
The difference in the fibrosis progression of recurrent hepatitis C after live donor liver transplantation versus deceased donor liver transplantation is attributable to the difference in donor age
Nazia Selzner, Nigel Girgrah, Les Lilly, Maha Guindi, Markus Selzner, George Therapondos, Oyedele Adeyi, Ian McGilvray, Mark Cattral, Paul D. Greig, David Grant, Gary Levy, Eberhard L. Renner – 24 November 2008 – Hepatitis C recurs universally after liver transplantation (LT). Whether its progression differs after live donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) is still debated.
Comparison of a new enzymatic assay with a high‐performance liquid chromatography/ ultraviolet detection method for therapeutic drug monitoring of mycophenolic acid in adult liver transplant recipients
Benoit Blanchet, Fabrice Taieb, Filomena Conti, Halim Abbas, Idrissa Seydi, Laura Harcouet, Alain Dauphin, Yvon Calmus, Michel Tod – 24 November 2008 – Mycophenolic acid (MPA) is used to prevent graft rejection. The methods used for determining the plasma MPA concentration in liver transplant recipients are the enzyme‐multiplied immunoassay technique (EMIT), high‐performance liquid chromatography with ultraviolet detection (HPLC‐UV), and most recently mass spectrometry. EMIT has been reported to overestimate the MPA concentration by 30% to 35% in comparison with HPLC‐UV.