Continuous right ventricular end diastolic volume and right ventricular ejection fraction during liver transplantation: A multicenter study

Giorgio Della Rocca, Maria Gabriella Costa, Paolo Feltracco, Gianni Biancofiore, Bruno Begliomini, Stefania Taddei, Cecilia Coccia, Livia Pompei, Pierangelo Di Marco, Paolo Pietropaoli – 27 February 2008 – Cardiac preload is traditionally considered to be represented by its filling pressures, but more recently, estimations of end diastolic volume of the left or right ventricle have been shown to better reflect preload.

A molecular link between inflammation and fibrogenesis: The bacterial microflora influences hepatic fibrosis via toll‐like receptor 4–dependent modification of transforming growth factor‐β signaling in hepatic stellate cells

Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis

Rubén Francés, Pedro Zapater, José M. González‐Navajas, Carlos Muñoz, Rocío Caño, Rocío Moreu, Sonia Pascual, Pablo Bellot, Miguel Pérez‐Mateo, José Such – 27 February 2008 – Bacterial infections and severity of associated inflammatory reaction influence prognosis in patients with advanced cirrhosis. We compared the innate immune response to bacterial DNA (bactDNA) translocation with that caused by viable bacteria translocation in patients with spontaneous bacterial peritonitis and the relationship between the cytokine response and serum levels of bactDNA.

“Splenic artery steal syndrome” is a misnomer: The cause is portal hyperperfusion, not arterial siphon

Cristiano Quintini, Kenzo Hirose, Koji Hashimoto, Teresa Diago, Federico Aucejo, Bijan Eghtesad, David Vogt, Gregory Pierce, Mark Baker, Dympna Kelly, Charles M. Miller – 27 February 2008 – Splenic artery embolization (SAE) improves hepatic artery (HA) flow in liver transplant (OLT) recipients with so‐called splenic artery steal syndrome. We propose that SAE actually improves HA flow by reducing the HA buffer response (HABR). Patient 1: On postoperative day (POD) 1, Doppler ultrasonography (US) showed patent vasculature with HA resistive index (RI) of 0.8.

The cyclophilin inhibitor Debio‐025 shows potent anti–hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus

Robert Flisiak, Andrzej Horban, Philippe Gallay, Michael Bobardt, Suganya Selvarajah, Alicja Wiercinska‐Drapalo, Ewa Siwak, Iwona Cielniak, Jozef Higersberger, Jarek Kierkus, Christian Aeschlimann, Pierre Grosgurin, Valérie Nicolas‐Métral, Jean‐Maurice Dumont, Hervé Porchet, Raf Crabbé, Pietro Scalfaro – 26 February 2008 – Debio‐025 is an oral cyclophilin (Cyp) inhibitor with potent anti–hepatitis C virus activity in vitro. Its effect on viral load as well as its influence on intracellular Cyp levels was investigated in a randomized, double‐blind, placebo‐controlled study.

Liver disease in pregnancy

J. Eileen Hay – 26 February 2008 – Abnormal liver tests occur in 3%–5% of pregnancies, with many potential causes, including coincidental liver disease (most commonly viral hepatitis or gallstones) and underlying chronic liver disease. However, most liver dysfunction in pregnancy is pregnancy‐related and caused by 1 of the 5 liver diseases unique to the pregnant state: these fall into 2 main categories depending on their association with or without preeclampsia.

Comprehensive and quantitative proteome profiling of the mouse liver and plasma

Keane K. Y. Lai, Deepak Kolippakkam, Laura Beretta – 26 February 2008 – We report a comprehensive and quantitative analysis of the mouse liver and plasma proteomes. The method used is based on extensive fractionation of intact proteins, further separation of proteins based on their abundance and size, and high‐accuracy mass spectrometry. This analysis reached a depth in proteomic profiling not reported to date for a mammalian tissue or a biological fluid, with 7099 and 4727 proteins identified with high confidence in the liver and in the corresponding plasma, respectively.

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